| Literature DB >> 26294353 |
Vasso Apostolopoulos1, Lily Stojanovska2, Sharron E Gargosky3.
Abstract
Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.Entities:
Keywords: CD227; EMA; MUC1; MUC1 and cancer; MUC1 and disease; MUC1 and pathogens; MUC1 expression; MUC1 isoforms; MUC1 structure; PEM
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Year: 2015 PMID： 26294353 DOI： 10.1007/s00018-015-2014-z
Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261