Jinzhuo Zhao1, Liang Bo2, Changyi Gong3, Peng Cheng4, Haidong Kan5, Yuquan Xie6, Weimin Song7. 1. Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety). Jinzhuozhao@fudan.edu.cn. 2. Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety). Liang@163.com. 3. Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety). Gong@126.com. 4. No. 3 People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China (Department of Gastroenterology). chengp@gmail.com. 5. Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety). Haidong@gmail.com. 6. Shanghai Jiao Tong University, Shanghai, China (Department of Cardiology, Xinhua Hospital, School of Medicine). xyqah@163.com. 7. Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety). wmsong1@gmail.com.
Abstract
OBJECTIVES: Traffic-related particulate matter (PM) is one of the major sources of air pollution in metropolitan areas. This study is to observe the interactive effects of gene and fine particles (particles smaller than 2.5 μm - PM2.5) on the respiratory system and explore the mechanisms linking PM2.5 and pulmonary injury. MATERIAL AND METHODS: The participants include 110 traffic policemen and 101 common populations in Shanghai, China. Continuous 24 h individual-level PM2.5 is detected and the pulmonary function, high-sensitivity C-reactive protein (hs-CRP), Clara cell protein 16 (CC16) and the polymorphism in CXCL3, NME7 and C5 genes are determined. The multiple linear regression method is used to analyze the association between PM2.5 and health effects. Meanwhile, the interactive effects of gene and PM2.5 on lung function are analyzed. RESULTS: The individual PM2.5 exposure for traffic policemen was higher than that in the common population whereas the forced expiratory volume in 1 s (FEV1), the ratio of FEV1 to forced vital capacity (FEV1/FVC) and lymphocytes are lower. In contrast, the hs-CRP level is higher. In the adjusted analysis, PM2.5 exposure was associated with the decrease in lymphocytes and the increase in hs-CRP. The allele frequencies for NME7 and C5 have significant differences between FEV1/FVC ≤ 70% and FEV1/FVC > 70% participants. The results didn't find the interaction effects of gene and PM2.5 on FEV1/FVC in all the 3 genes. CONCLUSIONS: The results indicated that traffic exposure to high levels of PM2.5 was associated with systemic inflammatory response and respiratory injury. Traffic policemen represent a high risk group suffering from the respiratory injury. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
OBJECTIVES: Traffic-related particulate matter (PM) is one of the major sources of air pollution in metropolitan areas. This study is to observe the interactive effects of gene and fine particles (particles smaller than 2.5 μm - PM2.5) on the respiratory system and explore the mechanisms linking PM2.5 and pulmonary injury. MATERIAL AND METHODS: The participants include 110 traffic policemen and 101 common populations in Shanghai, China. Continuous 24 h individual-level PM2.5 is detected and the pulmonary function, high-sensitivity C-reactive protein (hs-CRP), Clara cell protein 16 (CC16) and the polymorphism in CXCL3, NME7 and C5 genes are determined. The multiple linear regression method is used to analyze the association between PM2.5 and health effects. Meanwhile, the interactive effects of gene and PM2.5 on lung function are analyzed. RESULTS: The individual PM2.5 exposure for traffic policemen was higher than that in the common population whereas the forced expiratory volume in 1 s (FEV1), the ratio of FEV1 to forced vital capacity (FEV1/FVC) and lymphocytes are lower. In contrast, the hs-CRP level is higher. In the adjusted analysis, PM2.5 exposure was associated with the decrease in lymphocytes and the increase in hs-CRP. The allele frequencies for NME7 and C5 have significant differences between FEV1/FVC ≤ 70% and FEV1/FVC > 70% participants. The results didn't find the interaction effects of gene and PM2.5 on FEV1/FVC in all the 3 genes. CONCLUSIONS: The results indicated that traffic exposure to high levels of PM2.5 was associated with systemic inflammatory response and respiratory injury. Traffic policemen represent a high risk group suffering from the respiratory injury. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.
Entities:
Keywords:
SNP; fine particles; inflammation; respiratory system; single nucleotide polymorphism; traffic workers