Meysam Moghbeli1, Mohammad Mahdi Forghanifard2, Ali Sadrizadeh3, Hooman Mosannen Mozaffari4, Ebrahim Golmakani5, Mohammad Reza Abbaszadegan6,7. 1. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran. 3. Cardiothoracic Surgery and Transplant Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 4. Department of Gastroenterology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. 5. Department of Anesthesiology and Critical Care, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. AbbaszadeganMR@mums.ac.ir. 7. Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran. AbbaszadeganMR@mums.ac.ir.
Abstract
PURPOSE: Developmental pathways such as Wnt and Notch are involved in different cellular functions from the cell cycle regulation to self-renewal. Therefore, aberrations in these pathways may cause tumorigenesis. Msi1 has a critical regulatory role for the Wnt and Notch pathways. In the present study, we have assessed the probable correlation between the Msi1 and MAML1 in esophageal squamous cell carcinoma (ESCC) progression and metastasis. METHODS: Levels of Msi1 and MAML1 mRNA expression in 51 ESCC patients were compared to the normal tissues using real-time polymerase chain reaction (PCR). RESULTS: Nine out of 51 (17.6 %) cases had Msi1/MAML1 overexpression, and there was a significant correlation between such overexpressed cases and tumor location (p = 0.013). CONCLUSIONS: We showed that there is not any direct correlation and feedback between the Msi1 and MAML1 in ESCC patients.
PURPOSE: Developmental pathways such as Wnt and Notch are involved in different cellular functions from the cell cycle regulation to self-renewal. Therefore, aberrations in these pathways may cause tumorigenesis. Msi1 has a critical regulatory role for the Wnt and Notch pathways. In the present study, we have assessed the probable correlation between the Msi1 and MAML1 in esophageal squamous cell carcinoma (ESCC) progression and metastasis. METHODS: Levels of Msi1 and MAML1 mRNA expression in 51 ESCC patients were compared to the normal tissues using real-time polymerase chain reaction (PCR). RESULTS: Nine out of 51 (17.6 %) cases had Msi1/MAML1 overexpression, and there was a significant correlation between such overexpressed cases and tumor location (p = 0.013). CONCLUSIONS: We showed that there is not any direct correlation and feedback between the Msi1 and MAML1 in ESCC patients.
Entities:
Keywords:
Cancer stem cell; Gene expression; Inhibitor; Real time PCR; Signaling pathway; Translation
Authors: Cathrin Brisken; Ayyakkannu Ayyannan; Cuc Nguyen; Anna Heineman; Ferenc Reinhardt; Jian Tan; S K Dey; G Paolo Dotto; Robert A Weinberg; Tian Jan Journal: Dev Cell Date: 2002-12 Impact factor: 12.270
Authors: Russell C Hovey; Jessica Harris; Darryl L Hadsell; Adrian V Lee; Christopher J Ormandy; Barbara K Vonderhaar Journal: Mol Endocrinol Date: 2002-12-23