Juan C Ramirez-Sandoval1, Ivan Casanova2, Alejandro Villar3, F Enrique Gomez4, Cristino Cruz3, Ricardo Correa-Rotter3. 1. Department of Nephrology and Mineral Metabolism, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico carlos.ramirezs@incmnsz.mx. 2. Department of Radiology, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico. 3. Department of Nephrology and Mineral Metabolism, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico. 4. Department of Physiology of Nutrition, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico.
Abstract
UNLABELLED: ♦ BACKGROUND: Vascular calcification is strongly associated with cardiovascular disease and mortality. However, some factors related to vascular calcification in patients with end-stage renal disease receiving peritoneal dialysis (PD) remain unknown. This study aimed to evaluate the associations of osteoprotegerin (OPG), osteopontin (OPN), osteocalcin (OCN), fibroblast growth factor 23 (FGF-23), magnesium, and phosphate clearance with vascular calcification in PD subjects, assessed by plain radiographs. ♦ METHODS: Simple vascular calcification scores (SVCS) obtained from plain X-rays of the pelvis and hands, and the Kauppila Index (KI) from lateral lumbar X-rays were assessed in 76 adults receiving PD for ≥ 6 months (43 women, median age 39 years, median time on PD 1.4 years). Levels of OPG, OPN, OCN, and FGF-23 were determined by luminometry. ♦ RESULTS: Serum OPG levels were higher in subjects with vascular calcification (n = 22 with SVCS > 3; n = 19 with KI > 7) compared with those with less calcification (p < 0.001). Spearman's correlation coefficients between OPG and SVCS and KI were r = 0.49 and r = 0.51, respectively (both p < 0.001). Subjects with vascular calcification had significantly lower renal phosphate clearance. Multiple regression analysis showed that vascular calcification assessed by SVCS was associated with age (r = 0.2, p = 0.042), diabetes mellitus (r = 2.4, p < 0.001), body mass index (BMI) (r = 0.09, p = 0.037), and OPG (r = 0.22, p = 0.001). Vascular calcification assessed by KI was associated with age (r = 0.16, p < 0.001), time on PD (r = 0.54, p = 0.001) and OPG (r = 0.08, p = 0.04). Osteocalcin, OPN, FGF-23, and magnesium were not associated with vascular calcification. ♦ CONCLUSIONS: Higher levels of OPG were consistently associated with vascular calcification in subjects on PD.
UNLABELLED: ♦ BACKGROUND:Vascular calcification is strongly associated with cardiovascular disease and mortality. However, some factors related to vascular calcification in patients with end-stage renal disease receiving peritoneal dialysis (PD) remain unknown. This study aimed to evaluate the associations of osteoprotegerin (OPG), osteopontin (OPN), osteocalcin (OCN), fibroblast growth factor 23 (FGF-23), magnesium, and phosphate clearance with vascular calcification in PD subjects, assessed by plain radiographs. ♦ METHODS: Simple vascular calcification scores (SVCS) obtained from plain X-rays of the pelvis and hands, and the Kauppila Index (KI) from lateral lumbar X-rays were assessed in 76 adults receiving PD for ≥ 6 months (43 women, median age 39 years, median time on PD 1.4 years). Levels of OPG, OPN, OCN, and FGF-23 were determined by luminometry. ♦ RESULTS: Serum OPG levels were higher in subjects with vascular calcification (n = 22 with SVCS > 3; n = 19 with KI > 7) compared with those with less calcification (p < 0.001). Spearman's correlation coefficients between OPG and SVCS and KI were r = 0.49 and r = 0.51, respectively (both p < 0.001). Subjects with vascular calcification had significantly lower renal phosphate clearance. Multiple regression analysis showed that vascular calcification assessed by SVCS was associated with age (r = 0.2, p = 0.042), diabetes mellitus (r = 2.4, p < 0.001), body mass index (BMI) (r = 0.09, p = 0.037), and OPG (r = 0.22, p = 0.001). Vascular calcification assessed by KI was associated with age (r = 0.16, p < 0.001), time on PD (r = 0.54, p = 0.001) and OPG (r = 0.08, p = 0.04). Osteocalcin, OPN, FGF-23, and magnesium were not associated with vascular calcification. ♦ CONCLUSIONS: Higher levels of OPG were consistently associated with vascular calcification in subjects on PD.
Authors: Roger J M W Rennenberg; Peter W de Leeuw; Alphons G H Kessels; Leon J Schurgers; Cees Vermeer; Jos M A van Engelshoven; Gerrit J Kemerink; Abraham A Kroon Journal: Eur J Clin Invest Date: 2010-04 Impact factor: 4.686
Authors: Juan C Ramirez-Sandoval; Mauricio Arvizu-Hernandez; Cristino Cruz; Barbara Vazquez-Cantu; Luis J Rojas-Concha; Luis Tamez; Fagundo Reynerio; F Enrique Gomez; Ricardo Correa-Rotter Journal: J Nephrol Date: 2019-03-19 Impact factor: 3.902
Authors: Sophie A Millar; Hinal Patel; Susan I Anderson; Timothy J England; Saoirse E O'Sullivan Journal: Front Endocrinol (Lausanne) Date: 2017-07-31 Impact factor: 5.555