Literature DB >> 26293348

Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer.

Shelley B Hooks1, Mandi M Murph1.   

Abstract

More than 30 regulators of G protein signaling (RGS) proteins encompass the RGS protein superfamily of critical regulators essential to cellular homeostasis. There is enormous structural and functional diversity among the RGS superfamily, and as such they serve a wide range of functions in regulating cell biology and physiology. Recent evidence has suggested roles for multiple RGS proteins in cancer initiation and progression, which has prompted research toward the potential modulation of these proteins as a new approach in cancer therapy. This article will discuss basic RGS molecular pharmacology, summarize the cellular functions and epigenetic regulation of RGS10, review ovarian cancer chemotherapy and describe the role of RGS10 in ovarian cancer survival signaling.

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Year:  2015        PMID： 26293348      PMCID： PMC4597593          DOI： 10.4155/fmc.15.81

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  24 in total

1.  Rethinking ovarian cancer: recommendations for improving outcomes.

Authors:  Sebastian Vaughan; Jermaine I Coward; Robert C Bast; Andy Berchuck; Jonathan S Berek; James D Brenton; George Coukos; Christopher C Crum; Ronny Drapkin; Dariush Etemadmoghadam; Michael Friedlander; Hani Gabra; Stan B Kaye; Chris J Lord; Ernst Lengyel; Douglas A Levine; Iain A McNeish; Usha Menon; Gordon B Mills; Kenneth P Nephew; Amit M Oza; Anil K Sood; Euan A Stronach; Henning Walczak; David D Bowtell; Frances R Balkwill
Journal:  Nat Rev Cancer       Date:  2011-09-23       Impact factor: 60.716

2.  CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis.

Authors:  Gong Yang; Daniel G Rosen; Guangzhi Liu; Fan Yang; Xiaoqing Guo; Xue Xiao; Fengxia Xue; Imelda Mercado-Uribe; Jiaoti Huang; Sue-Hwa Lin; Gordon B Mills; Jinsong Liu
Journal:  Clin Cancer Res       Date:  2010-05-26       Impact factor: 12.531

3.  Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation.

Authors:  Shuying Yang; Wei Chen; Philip Stashenko; Yi-Ping Li
Journal:  J Cell Sci       Date:  2007-10-01       Impact factor: 5.285

Review 4.  Endocrine signaling in ovarian surface epithelium and cancer.

Authors:  Peter C K Leung; Jung-Hye Choi
Journal:  Hum Reprod Update       Date:  2006-10-27       Impact factor: 15.610

5.  Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.

Authors:  Shelley B Hooks; Phillip Callihan; Molly K Altman; Jillian H Hurst; Mourad W Ali; Mandi M Murph
Journal:  Mol Cancer       Date:  2010-11-02       Impact factor: 27.401

Review 6.  Minireview: epigenetic changes in ovarian cancer.

Authors:  Curt Balch; Fang Fang; Daniela E Matei; Tim H-M Huang; Kenneth P Nephew
Journal:  Endocrinology       Date:  2009-07-02       Impact factor: 4.736

7.  Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924.

Authors:  Amir A Jazaeri; Etsuko Shibata; Jonghoon Park; Jennifer L Bryant; Mark R Conaway; Susan C Modesitt; Peter G Smith; Michael A Milhollen; Allison J Berger; Anindya Dutta
Journal:  Mol Cancer Ther       Date:  2013-08-12       Impact factor: 6.261

8.  RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation.

Authors:  Shuying Yang; Yi-Ping Li
Journal:  Genes Dev       Date:  2007-07-12       Impact factor: 11.361

9.  Transcriptional suppression, DNA methylation, and histone deacetylation of the regulator of G-protein signaling 10 (RGS10) gene in ovarian cancer cells.

Authors:  Mourad W Ali; Ercan Cacan; Yuying Liu; Jennifer Young Pierce; William T Creasman; Mandi M Murph; Rajgopal Govindarajan; Scott T Eblen; Susanna F Greer; Shelley B Hooks
Journal:  PLoS One       Date:  2013-03-22       Impact factor: 3.240

10.  Critical role of regulator G-protein signaling 10 (RGS10) in modulating macrophage M1/M2 activation.

Authors:  Jae-Kyung Lee; Jaegwon Chung; George T Kannarkat; Malú G Tansey
Journal:  PLoS One       Date:  2013-11-21       Impact factor: 3.240
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  4 in total

Review 1.  Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease.

Authors:  Katherine E Squires; Carolina Montañez-Miranda; Rushika R Pandya; Matthew P Torres; John R Hepler
Journal:  Pharmacol Rev       Date:  2018-07       Impact factor: 25.468

2.  RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein-Independent Mechanism.

Authors:  Mohammed Alqinyah; Faris Almutairi; Menbere Y Wendimu; Shelley B Hooks
Journal:  Mol Pharmacol       Date:  2018-07-26       Impact factor: 4.436

3.  RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.

Authors:  Menbere Y Wendimu; Mohammed Alqinyah; Stephen Vella; Phillip Dean; Faris Almutairi; Roseanne Davila-Rivera; Shima Rayatpisheh; James Wohlschlegel; Silvia Moreno; Shelley B Hooks
Journal:  Cell Signal       Date:  2021-03-09       Impact factor: 4.850

4.  PI3K/ NF-κB-dependent TNF-α and HDAC activities facilitate LPS-induced RGS10 suppression in pulmonary macrophages.

Authors:  Faris Almutairi; Samantha L Tucker; Demba Sarr; Balázs Rada
Journal:  Cell Signal       Date:  2021-07-31       Impact factor: 4.850
  4 in total

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