S Bubenzer-Busch1,2,3, B Herpertz-Dahlmann1,3, B Kuzmanovic4,5, T J Gaber1,3, K Helmbold1,3, M G Ullisch6,7, D Baurmann1,2,3, S B Eickhoff8,9, G R Fink2,10, F D Zepf1,2,3,11,12. 1. Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany. 2. Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Jülich Research Centre, Jülich, Germany. 3. JARA Translational Brain Medicine, Aachen, Jülich, Germany. 4. Institute of Neuroscience and Medicine (INM-8), Ethics in the Neurosciences, Jülich Research Centre, Jülich, Germany. 5. Department of Psychiatry and Psychotherapy, Neuroimaging Lab, University Hospital Cologne, Cologne, Germany. 6. Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Jülich Research Centre, Jülich, Germany. 7. Interdisciplinary Nanoscience Center, iNANO, University of Aarhus, Aarhus, Denmark. 8. Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Düsseldorf, Germany. 9. Institute of Neuroscience and Medicine (INM-1), Institute of Clinical Neuroscience and Medical Psychology - Brain Network Modeling Group, Jülich Research Centre, Jülich, Germany. 10. Department of Neurology, University of Cologne, Cologne, Germany. 11. Department of Child and Adolescent Psychiatry, Faculty of Medicine, Dentistry and Health Sciences, School of Psychiatry and Clinical Neurosciences & School of Pediatrics and Child Health, The University of Western Australia, Perth, WA, Australia. 12. Specialised Child and Adolescent Mental Health Services (CAMHS), Department of Health in Western Australia, Perth, WA, Australia.
Abstract
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is often linked with impulsive and aggressive behaviour, indexed by high comorbidity rates between ADHD and disruptive behaviour disorders (DBD). The present study aimed to investigate underlying neural activity of reactive aggression in children with ADHD and comorbid DBD using functional neuroimaging techniques (fMRI). METHOD: Eighteen boys with ADHD (age 9-14 years, 10 subjects with comorbid DBD) and 18 healthy controls were administered a modified fMRI-based version of the 'Point Subtraction Aggression Game' to elicit reactive aggressive behaviour. Trials consisted of an 'aggression phase' (punishment for a fictitious opponent) and an 'outcome phase' (presentation of the trial outcome). RESULTS: During the aggression phase, higher aggressive responses of control children were accompanied by higher activation of the ventral anterior cingulate cortex and the temporoparietal junction. Patients displayed inverted results. During the outcome phase, comparison between groups and conditions showed differential activation in the dorsal striatum and bilateral insular when subjects gained points. Losing points was accompanied by differential activation of regions belonging to the insula and the middle temporal sulcus. CONCLUSION: Data support the hypothesis that deficient inhibitory control mechanisms are related to increased impulsive aggressive behaviour in young people with ADHD and comorbid DBD.
OBJECTIVE:Attention deficit hyperactivity disorder (ADHD) is often linked with impulsive and aggressive behaviour, indexed by high comorbidity rates between ADHD and disruptive behaviour disorders (DBD). The present study aimed to investigate underlying neural activity of reactive aggression in children with ADHD and comorbid DBD using functional neuroimaging techniques (fMRI). METHOD: Eighteen boys with ADHD (age 9-14 years, 10 subjects with comorbid DBD) and 18 healthy controls were administered a modified fMRI-based version of the 'Point Subtraction Aggression Game' to elicit reactive aggressive behaviour. Trials consisted of an 'aggression phase' (punishment for a fictitious opponent) and an 'outcome phase' (presentation of the trial outcome). RESULTS: During the aggression phase, higher aggressive responses of control children were accompanied by higher activation of the ventral anterior cingulate cortex and the temporoparietal junction. Patients displayed inverted results. During the outcome phase, comparison between groups and conditions showed differential activation in the dorsal striatum and bilateral insular when subjects gained points. Losing points was accompanied by differential activation of regions belonging to the insula and the middle temporal sulcus. CONCLUSION: Data support the hypothesis that deficient inhibitory control mechanisms are related to increased impulsive aggressive behaviour in young people with ADHD and comorbid DBD.
Authors: S Neufang; A Akhrif; C G Herrmann; C Drepper; G A Homola; J Nowak; J Waider; A G Schmitt; K-P Lesch; M Romanos Journal: Transl Psychiatry Date: 2016-11-08 Impact factor: 6.222
Authors: S Weissenberger; M Klicperova-Baker; P Zimbardo; K Schonova; D Akotia; J Kostal; M Goetz; J Raboch; R Ptacek Journal: Neuropsychiatr Dis Treat Date: 2016-11-16 Impact factor: 2.570
Authors: Florian D Zepf; Sarah Bubenzer-Busch; Kevin C Runions; Pradeep Rao; Janice W Y Wong; Simone Mahfouda; Hugo A E Morandini; Richard M Stewart; Julia K Moore; Caroline S Biskup; Simon B Eickhoff; Gereon R Fink; Robert Langner Journal: Brain Cogn Date: 2017-11-14 Impact factor: 2.310