Jingjing Li1, Lihong Zhang2, Chunfang Zhang3, Jye Yuan Cheng1, Jinrang Li4, Chieh-Fu Jeff Cheng5. 1. Department of Otolaryngology, Peking University People's Hospital, Beijing, China. 2. Department of Otolaryngology, Peking University People's Hospital, Beijing, China. Electronic address: lihongzhang@vip.sina.com. 3. Department of Clinical Epidemiology, Peking University People's Hospital, Beijing, China. 4. Department of Otolaryngology Head and Neck Surgery Center, Navy Army General Hospital, Beijing, China. 5. Department of Addiction and Mental Health, Rockyview General Hospital, Alberta Health Services, Calgary, Alberta, Canada.
Abstract
OBJECTIVES: Currently, there is no cost-effective tool available to diagnose laryngopharyngeal reflux (LPR) in the developing country of China. The aim of this study was to achieve a linguistic adaptation of the Chinese version of the Reflux Symptom Index (RSI-CH). STUDY DESIGN: A nonrandomized, controlled, prospective trial. METHODS: A total of 107 patients at the outpatient clinic of Peking University People's Hospital were enrolled. They were asked to fill out the RSI-CH and underwent fiber-optic laryngoscopy to complete the Reflux Finding Score (RFS). Patients underwent pH monitoring if the RSI-CH was greater than 13 or if the RFS was not less than 7. Patients were treated with Omeprazole 20 mg twice a day for 3 months if the pH monitoring was positive. The reliability (Cronbach alpha coefficient and Spearman correlation analysis), validity (sensitivity, specificity, and positive and negative predictive values), and responsivity of RSI-CH were determined. RESULTS: RSI-CH had a good reliability (Cronbach alpha coefficient was greater than .7, whereas the test-retest validity for the total score and for each item were 0.750-0.971. The scale had a good criterion validity. The consistency (66.7%), sensitivity (61.76%), and specificity (75%), and the positive and negative predictive values (80.8% and 53.6%) were considered good. The RSI-CH scores changed from 15 to 7 after treatment, and the average score of the controlled group was 6.5. CONCLUSIONS: The RSI-CH developed and validated by this study can be used as an effective diagnostic tool in identifying differentiating LPR diseases in patients whose native language is Chinese.
OBJECTIVES: Currently, there is no cost-effective tool available to diagnose laryngopharyngeal reflux (LPR) in the developing country of China. The aim of this study was to achieve a linguistic adaptation of the Chinese version of the Reflux Symptom Index (RSI-CH). STUDY DESIGN: A nonrandomized, controlled, prospective trial. METHODS: A total of 107 patients at the outpatient clinic of Peking University People's Hospital were enrolled. They were asked to fill out the RSI-CH and underwent fiber-optic laryngoscopy to complete the Reflux Finding Score (RFS). Patients underwent pH monitoring if the RSI-CH was greater than 13 or if the RFS was not less than 7. Patients were treated with Omeprazole 20 mg twice a day for 3 months if the pH monitoring was positive. The reliability (Cronbach alpha coefficient and Spearman correlation analysis), validity (sensitivity, specificity, and positive and negative predictive values), and responsivity of RSI-CH were determined. RESULTS: RSI-CH had a good reliability (Cronbach alpha coefficient was greater than .7, whereas the test-retest validity for the total score and for each item were 0.750-0.971. The scale had a good criterion validity. The consistency (66.7%), sensitivity (61.76%), and specificity (75%), and the positive and negative predictive values (80.8% and 53.6%) were considered good. The RSI-CH scores changed from 15 to 7 after treatment, and the average score of the controlled group was 6.5. CONCLUSIONS: The RSI-CH developed and validated by this study can be used as an effective diagnostic tool in identifying differentiating LPR diseases in patients whose native language is Chinese.
Authors: Giannicola Iannella; Claudio Vicini; Antonella Polimeni; Antonio Greco; Riccardo Gobbi; Filippo Montevecchi; Andrea De Vito; Giuseppe Meccariello; Giovanni Cammaroto; Giovanni D'Agostino; Annalisa Pace; Raffaella Cascella; Marco Brunori; Cristina Anna Maria Lo Iacono; Stefano Pelucchi; Giuseppe Magliulo Journal: Int J Environ Res Public Health Date: 2019-06-10 Impact factor: 3.390