Jie-Ping Wan1, Shuo Cao1, Yunyun Liu1. 1. Key Laboratory of Functional Small Organic Molecules, Ministry of Education, and College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, PR China.
Abstract
The construction of 1,5-disubstituted 1,2,3-triazoles has been effected through the cascade dual C-N bond formation, N-N bond formation and an acyl migration-based C-C bond formation via the three-component reactions of enaminones, tosylhydrazine and primary amines. This metal- and azide-free, regioselective synthetic method proceeds in the presence of only molecular iodine.
The construction of 1,5-disubstitutedn class="Chemical">1,2,3-triazoles has been effected through the cascade dual C-N bond formation, N-N bond formation and an acyl migration-based C-C bond formation via the three-component reactions of enaminones, tosylhydrazine and primary amines. This metal- and azide-free, regioselective synthetic method proceeds in the presence of only molecular iodine.