Literature DB >> 26290171

A mild and regioselective route to functionalized quinazolines.

Tracy M M Maiden1, Stephen Swanson2, Panayiotis A Procopiou2, Joseph P A Harrity3.   

Abstract

A Rh-catalyzed ortho-amidation cyclocondensation sequence gave a range of 4-aminoquinazolines in high yield. The method features a remarkably mild C(sp(2) )H activation step and can be exploited to rapidly access compounds with established biological activity.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  amidation; cyclization; homogeneous catalysis; oxazolines; quinazolines

Mesh：

Substances：

Year:  2015        PMID： 26290171     DOI： 10.1002/chem.201502891

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  2 in total

Review 1.  A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry.

Authors:  Carlo Sambiagio; David Schönbauer; Remi Blieck; Toan Dao-Huy; Gerit Pototschnig; Patricia Schaaf; Thomas Wiesinger; Muhammad Farooq Zia; Joanna Wencel-Delord; Tatiana Besset; Bert U W Maes; Michael Schnürch
Journal:  Chem Soc Rev       Date:  2018-08-28       Impact factor: 54.564

2.  Intermolecular Aryl C-H Amination through Sequential Iron and Copper Catalysis.

Authors:  Mohamed A B Mostafa; Ewen D D Calder; Daugirdas T Racys; Andrew Sutherland
Journal:  Chemistry       Date:  2016-12-16       Impact factor: 5.236
  2 in total

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