Literature DB >> 26290162

Novel insight for midline cyst formation in prostate: The involvement of decreased prenatal testosterone suggested by second-to-fourth digit ratio study.

Seiji Furuya1, Shin-Ichi Hisasue2, Haruaki Kato3, Shogo Shimamura4.   

Abstract

OBJECTIVES: To clarify the relationship between midline cyst formation and second to fourth finger length ratio.
METHODS: The present study included 95 benign prostatic hyperplasia patients and 61 healthy male college students. All midline cysts were identified by transrectal ultrasonography. In the benign prostatic hyperplasia group, 45 midline cyst (+) men (M(age) = 67.2 years) and age-matched 50 midline cyst (-) men (M(age) = 67.1 years) were included. In the university student group, 12 midline cyst (+) men (M(age) = 21.7 years) and age-matched 49 midline cyst (-) men (Mage = 21.1 years) were included. We took photocopies of the participants' bilateral hands, and measured the second and fourth finger length was measured by one examiner in a blind manner.
RESULTS: Second to fourth finger length ratios in the benign prostatic hyperplasia group (right/left mean ± SD) were higher bilaterally in midline cyst (+) (0.95 ± 0.03/0.95 ± 0.03) than those in midline cyst (-) (0.92 ± 0.03/0.92 ± 0.03; P < 0.0001/P = 0.0010). Second to fourth finger length ratios in students were higher only in the right hand in midline cyst (+) (0.96 ± 0.03/0.94 ± 0.03) than those in midline cyst (-) (0.93 ± 0.03/0.94 ± 0.03; P = 0.0018/P = 0.9968). The second to fourth finger length ratio of midline cyst (+) men was significantly higher than that in midline cyst (-) men.
CONCLUSIONS: The second to fourth finger length ratio is higher in subjects with midline cyst of the prostate. It can be speculated that the prostatic utricle dilates in cases less exposed to male hormones during fetal development.
© 2015 The Japanese Urological Association.

Entities:  

Keywords:  2D:4D; digit ratio; midline cyst; prostate; testosterone

Mesh:

Substances:

Year:  2015        PMID: 26290162     DOI: 10.1111/iju.12892

Source DB:  PubMed          Journal:  Int J Urol        ISSN: 0919-8172            Impact factor:   3.369


  3 in total

1.  Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study.

Authors:  Guanjian Li; Ke Sun; Jie Guo; Shixing Li; Bo Li; Jing Cao; Pengfei Lu; Jiajia Yang; Ying Zhang; Xin Yang; Le Gao; Yi He; Tao Cui; Bin Ma
Journal:  Sci Rep       Date:  2017-07-12       Impact factor: 4.379

2.  New technique for the management of anteriorly located midline prostatic cysts causing severe lower urinary tract symptoms: Case report and literature review.

Authors:  Khalid Abdulrahman Al-Nasser; Raed Mohammed Almannie
Journal:  Int J Surg Case Rep       Date:  2019-01-29

Review 3.  Duplication of SOX3 in an SRY-negative 46,XX male with prostatic utricle: case report and literature review.

Authors:  Jiansheng Wei; Changrong Liu; Minyan Zhang; Shen Liu; Junjie Fu; Peng Lin
Journal:  BMC Med Genomics       Date:  2022-09-05       Impact factor: 3.622

  3 in total

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