Literature DB >> 26289975

Safety, immunogenicity and infectivity of new live attenuated influenza vaccines.

Irina Isakova-Sivak1, Larisa Rudenko.   

Abstract

Live attenuated influenza vaccines (LAIVs) are believed to be immunologically superior to inactivated influenza vaccines, because they can induce a variety of adaptive immune responses, including serum antibodies, mucosal and cell-mediated immunity. In addition to the licensed cold-adapted LAIV backbones, a number of alternative LAIV approaches are currently being developed and evaluated in preclinical and clinical studies. This review summarizes recent progress in the development and evaluation of LAIVs, with special attention to their safety, immunogenicity and infectivity for humans, and discusses their perspectives for the future.

Entities:  

Keywords:  immunogenicity; licensure criteria; live attenuated influenza vaccine; pandemic influenza; safety; seasonal influenza; vaccine virus shedding

Mesh：

Substances：

Year:  2015        PMID： 26289975     DOI： 10.1586/14760584.2015.1075883

Source DB:  PubMed          Journal:  Expert Rev Vaccines        ISSN： 1476-0584            Impact factor:   5.217


  14 in total

1.  Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes.

Authors:  Sinthujan Jegaskanda; Rosemarie D Mason; Sarah F Andrews; Adam K Wheatley; Ruijun Zhang; Glennys V Reynoso; David R Ambrozak; Celia P Santos; Catherine J Luke; Yumiko Matsuoka; Jason M Brenchley; Heather D Hickman; Kawsar R Talaat; Sallie R Permar; Hua-Xin Liao; Jonathan W Yewdell; Richard A Koup; Mario Roederer; Adrian B McDermott; Kanta Subbarao
Journal:  J Virol       Date:  2018-04-13       Impact factor: 5.103

Review 2.  Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic.

Authors:  William J Liu; Haixia Xiao; Lianpan Dai; Di Liu; Jianjun Chen; Xiaopeng Qi; Yuhai Bi; Yi Shi; George F Gao; Yingxia Liu
Journal:  Front Med       Date:  2021-04-16       Impact factor: 4.592

3.  Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo.

Authors:  Rebecca M Koch; Matthijs Kox; Eleonora J M Thijs; Janette C Rahamat-Langendoen; Frank L van de Veerdonk; Jelle Gerretsen; Joyce Schloesser; Dimitri Diavatopoulos; Guus F Rimmelzwaan; Mihai G Netea; Johannes G van der Hoeven; Marien I de Jonge; Peter Pickkers
Journal:  Front Immunol       Date:  2017-12-11       Impact factor: 7.561

Review 4.  Live Attenuated Reassortant Vaccines Based on A/Leningrad/134/17/57 Master Donor Virus Against H5 Avian Influenza.

Authors:  Irina Kiseleva; Natalie Larionova; Larisa Rudenko
Journal:  Open Microbiol J       Date:  2017-11-30

5.  Genotyping assay for differentiation of wild-type and vaccine viruses in subjects immunized with live attenuated influenza vaccine.

Authors:  Victoria Matyushenko; Irina Isakova-Sivak; Tatiana Smolonogina; Irina Dubrovina; Tatiana Tretiak; Larisa Rudenko
Journal:  PLoS One       Date:  2017-07-07       Impact factor: 3.240

Review 6.  Influenza vaccines: Evaluation of the safety profile.

Authors:  Claudia Maria Trombetta; Elena Gianchecchi; Emanuele Montomoli
Journal:  Hum Vaccin Immunother       Date:  2018-01-30       Impact factor: 3.452

7.  A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies.

Authors:  Randy A Albrecht; Florian Krammer; Raffael Nachbagauer; Wen-Chun Liu; Angela Choi; Teddy John Wohlbold; Talia Atlas; Madhusudan Rajendran; Alicia Solórzano; Francesco Berlanda-Scorza; Adolfo García-Sastre; Peter Palese
Journal:  NPJ Vaccines       Date:  2017-09-14       Impact factor: 7.344

8.  A Phase 1 Randomized Placebo-Controlled Study to Assess the Safety, Immunogenicity and Genetic Stability of a New Potential Pandemic H7N9 Live Attenuated Influenza Vaccine in Healthy Adults.

Authors:  Irina Kiseleva; Irina Isakova-Sivak; Marina Stukova; Marianna Erofeeva; Svetlana Donina; Natalie Larionova; Elena Krutikova; Ekaterina Bazhenova; Ekaterina Stepanova; Kirill Vasilyev; Victoria Matyushenko; Marina Krylova; Julia Galatonova; Aleksey Ershov; Dmitry Lioznov; Erin Grace Sparrow; Guido Torelli; Larisa Rudenko
Journal:  Vaccines (Basel)       Date:  2020-06-10

9.  A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study.

Authors:  Raffael Nachbagauer; Florian Krammer; Randy A Albrecht
Journal:  Vaccines (Basel)       Date:  2018-07-25

10.  SARS-CoV-2 will constantly sweep its tracks: a vaccine containing CpG motifs in 'lasso' for the multi-faced virus.

Authors:  V V Oberemok; K V Laikova; K A Yurchenko; N A Marochkin; I I Fomochkina; A V Kubyshkin
Journal:  Inflamm Res       Date:  2020-07-12       Impact factor: 6.986
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