| Literature DB >> 26287675 |
Abstract
Demethylation of the Foxp3 locus maintains gene expression and Treg cell stability. Yang et al. (2015) show that the gasotransmitter hydrogen sulfide co-operates with growth factor TGF-β and interleukin-2 to activate Tet-mediated DNA demethylation of Foxp3 to promote immune tolerance.Entities:
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Year: 2015 PMID: 26287675 DOI: 10.1016/j.immuni.2015.08.001
Source DB: PubMed Journal: Immunity ISSN: 1074-7613 Impact factor: 31.745