Literature DB >> 26286993

Disruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission.

Paul James Banks1, Amelia Caroline Burroughs1, Gareth Robert Isaac Barker1, Jon Thomas Brown2, Elizabeth Clea Warburton1, Zafar Iqbal Bashir3.   

Abstract

Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal-PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal-PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia.

Entities:  

Keywords:  D2R; NMDA receptor hypofunction; long-term depression; medial prefrontal cortex; schizophrenia

Mesh：

Substances：

Year:  2015        PMID： 26286993      PMCID： PMC4568284          DOI： 10.1073/pnas.1512064112

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  62 in total

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4.  Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay.

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5.  A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia.

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6.  Two serine residues on GluN2A C-terminal tails control NMDA receptor current decay times.

Authors:  Bruce A Maki; Ross Cole; Gabriela K Popescu
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7.  Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines.

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Review 8.  Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders.

Authors:  Yukiori Goto; Charles R Yang; Satoru Otani
Journal:  Biol Psychiatry       Date:  2009-10-14       Impact factor: 13.382

9.  Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity.

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10.  Age-dependent regulation of synaptic connections by dopamine D2 receptors.

Authors:  Jie-Min Jia; Jun Zhao; Zhonghua Hu; Daniel Lindberg; Zheng Li
Journal:  Nat Neurosci       Date:  2013-10-13       Impact factor: 24.884
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  9 in total

1.  Interneuron NMDA Receptor Ablation Induces Hippocampus-Prefrontal Cortex Functional Hypoconnectivity after Adolescence in a Mouse Model of Schizophrenia.

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Journal:  J Neurosci       Date:  2020-03-23       Impact factor: 6.167

2.  High frequency stimulation-induced plasticity in the prelimbic cortex of rats emerges during adolescent development and is associated with an increase in dopamine receptor function.

Authors:  Shuo Kang; Charles L Cox; Joshua M Gulley
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Review 3.  Modulation of NMDA Receptors by G-protein-coupled receptors: Role in Synaptic Transmission, Plasticity and Beyond.

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Review 4.  Adolescent Maturational Transitions in the Prefrontal Cortex and Dopamine Signaling as a Risk Factor for the Development of Obesity and High Fat/High Sugar Diet Induced Cognitive Deficits.

Authors:  Amy C Reichelt
Journal:  Front Behav Neurosci       Date:  2016-10-13       Impact factor: 3.558

5.  Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex.

Authors:  Marie H Sabec; Susan Wonnacott; E Clea Warburton; Zafar I Bashir
Journal:  Cell Rep       Date:  2018-03-27       Impact factor: 9.423

Review 6.  Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective.

Authors:  Amjad H Bazzari; H Rheinallt Parri
Journal:  Brain Sci       Date:  2019-10-31

7.  Dopamine D2 receptor regulates cortical synaptic pruning in rodents.

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8.  Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and Hippocampus.

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Journal:  Cereb Cortex Commun       Date:  2021-04-14

Review 9.  Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications.

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  9 in total

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