Soyeon Yoo1, Shinhang Moon1, Sang-Ouk Chin1, Sang-Ah Lee1,2, Changlim Hyun3, Gwanpyo Koh4,5. 1. Department of Internal Medicine, Jeju National University Hospital, 15, Aran 13-gil, Jeju-Si, Jeju-do, 690-767, Korea. 2. Department of Internal Medicine, Jeju National University School of Medicine, 15, Aran 13-gil, Jeju-Si, Jeju-do, 690-767, Korea. 3. Department of Pathology, Jeju National University School of Medicine, 15, Aran 13-gil, Jeju-Si, Jeju-do, 690-767, Korea. 4. Department of Internal Medicine, Jeju National University Hospital, 15, Aran 13-gil, Jeju-Si, Jeju-do, 690-767, Korea. okdom@jejunu.ac.kr. 5. Department of Internal Medicine, Jeju National University School of Medicine, 15, Aran 13-gil, Jeju-Si, Jeju-do, 690-767, Korea. okdom@jejunu.ac.kr.
Abstract
UNLABELLED: Case Kaposi's sarcoma (KS) is a malignant vascular tumor that occurs commonly in patients with acquired immunodeficiency syndrome. KS associated with Cushing's syndrome (CS) is unusual, especially in endogenous CS. Here, we report a case of KS associated with glucocorticoid-replacement therapy after surgical treatment for adrenal CS. A 70-year-old man presented with symptoms and signs of CS with a left adrenal mass. Adrenal CS was confirmed by biochemical studies. After left adrenalectomy, he took oral prednisolone (15 mg/day) to prevent adrenal insufficiency. Ten weeks later, numerous raised purple plaques on the lower extremities were newly detected. The biopsy findings were compatible with KS, but anti-HIV antibodies were negative. After withdrawal of glucocorticoid therapy, the skin lesions regressed completely. CONCLUSION: In this case, KS developed after the use of exogenous corticosteroid but not during endogenous hypercortisolism. This finding suggests that endogenous and exogenous corticosteroid play different roles in the development of KS.
UNLABELLED: Case Kaposi's sarcoma (KS) is a malignant vascular tumor that occurs commonly in patients with acquired immunodeficiency syndrome. KS associated with Cushing's syndrome (CS) is unusual, especially in endogenous CS. Here, we report a case of KS associated with glucocorticoid-replacement therapy after surgical treatment for adrenal CS. A 70-year-old man presented with symptoms and signs of CS with a left adrenal mass. Adrenal CS was confirmed by biochemical studies. After left adrenalectomy, he took oral prednisolone (15 mg/day) to prevent adrenal insufficiency. Ten weeks later, numerous raised purple plaques on the lower extremities were newly detected. The biopsy findings were compatible with KS, but anti-HIV antibodies were negative. After withdrawal of glucocorticoid therapy, the skin lesions regressed completely. CONCLUSION: In this case, KS developed after the use of exogenous corticosteroid but not during endogenous hypercortisolism. This finding suggests that endogenous and exogenous corticosteroid play different roles in the development of KS.
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