Literature DB >> 2628586

Severe alcohol intoxication: a study of 204 consecutive patients.

G E Minion1, C M Slovis, L Boutiette.   

Abstract

We report a five month retrospective analysis of 204 consecutive patients seen in an adult medical emergency department with blood alcohol concentrations (BAC) in excess of 400 mg/dl. The average BAC was 467 mg/dl with a range of 400-719 mg/dl. In 153 patients (75%) the BAC was 400-500 mg/dl, in 47 patients (23%) the BAC was 500-600 mg/dl and in 4 patients (2%) the BAC was greater than 600 mg/dl. Eighty-eight percent of the patients were oriented to person, place, and time upon questioning, 12% were disoriented or unresponsive to noxious stimuli. None of the four patients whose BAC was greater than 600 mg/dl were initially alert and oriented and only eight of the unresponsive patients had a BAC below 500 mg/dl (p less than .001). Sixteen patients (8%) were admitted. Three of the admissions were for continued unresponsiveness presumed due to ethanol, the other thirteen were for coexistent medical conditions. There were no significant associations between BAC and vital sign abnormalities.

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Mesh:

Year:  1989        PMID: 2628586     DOI: 10.3109/15563658909000358

Source DB:  PubMed          Journal:  J Toxicol Clin Toxicol        ISSN: 0731-3810


  11 in total

1.  Early alcohol exposure disrupts visual cortex plasticity in mice.

Authors:  Crystal L Lantz; Weili Wang; Alexandre E Medina
Journal:  Int J Dev Neurosci       Date:  2012-05-14       Impact factor: 2.457

2.  Alcohol-induced neuroapoptosis in the fetal macaque brain.

Authors:  Nuri B Farber; Catherine E Creeley; John W Olney
Journal:  Neurobiol Dis       Date:  2010-05-23       Impact factor: 5.996

3.  Phospholipase A2, oxidative stress, and neurodegeneration in binge ethanol-treated organotypic slice cultures of developing rat brain.

Authors:  Kwan-Hoon Moon; Nuzhath Tajuddin; James Brown; Edward J Neafsey; Hee-Yong Kim; Michael A Collins
Journal:  Alcohol Clin Exp Res       Date:  2013-08-01       Impact factor: 3.455

4.  Activation of cyclic GMP-dependent protein kinase blocks alcohol-mediated cell death and calcium disruption in cerebellar granule neurons.

Authors:  Dimitrios E Kouzoukas; Ramesh C Bhalla; Nicholas J Pantazis
Journal:  Neurosci Lett       Date:  2018-04-19       Impact factor: 3.046

5.  Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo.

Authors:  Kumar Sripathirathan; James Brown; Edward J Neafsey; Michael A Collins
Journal:  J Neurotrauma       Date:  2009-02-11       Impact factor: 5.269

6.  Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis.

Authors:  K Nixon; D H Kim; E N Potts; J He; F T Crews
Journal:  Neurobiol Dis       Date:  2008-05-03       Impact factor: 5.996

7.  Prenatal alcohol exposure enhances the susceptibility to NMDA-induced generalized tonic-clonic seizures in developing rats.

Authors:  Sue J Cho; David M Lovinger; Prosper N'Gouemo
Journal:  CNS Neurosci Ther       Date:  2017-10       Impact factor: 5.243

8.  Effect of alcohol on Glasgow Coma Scale in head-injured patients.

Authors:  Lance Stuke; Ramon Diaz-Arrastia; Larry M Gentilello; Shahid Shafi
Journal:  Ann Surg       Date:  2007-04       Impact factor: 12.969

9.  Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach.

Authors:  Dirk W Lachenmeier; Jürgen Rehm
Journal:  Sci Rep       Date:  2015-01-30       Impact factor: 4.379

10.  Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain.

Authors:  Catherine E Creeley; Krikor T Dikranian; Stephen A Johnson; Nuri B Farber; John W Olney
Journal:  Acta Neuropathol Commun       Date:  2013-06-12       Impact factor: 7.801

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