Literature DB >> 26284668

Protein degradation: Prime time for PROTACs.

Raymond J Deshaies1.   

Abstract

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Year:  2015        PMID： 26284668     DOI： 10.1038/nchembio.1887

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  13 in total

1.  Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.

Authors:  K M Sakamoto; K B Kim; A Kumagai; F Mercurio; C M Crews; R J Deshaies
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

2.  DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.

Authors:  Georg E Winter; Dennis L Buckley; Joshiawa Paulk; Justin M Roberts; Amanda Souza; Sirano Dhe-Paganon; James E Bradner
Journal:  Science       Date:  2015-05-21       Impact factor: 47.728

3.  Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

Authors:  Jing Lu; Yimin Qian; Martha Altieri; Hanqing Dong; Jing Wang; Kanak Raina; John Hines; James D Winkler; Andrew P Crew; Kevin Coleman; Craig M Crews
Journal:  Chem Biol       Date:  2015-06-04

4.  Identification of a primary target of thalidomide teratogenicity.

Authors:  Takumi Ito; Hideki Ando; Takayuki Suzuki; Toshihiko Ogura; Kentaro Hotta; Yoshimasa Imamura; Yuki Yamaguchi; Hiroshi Handa
Journal:  Science       Date:  2010-03-12       Impact factor: 47.728

5.  Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.

Authors:  Jan Krönke; Namrata D Udeshi; Anupama Narla; Peter Grauman; Slater N Hurst; Marie McConkey; Tanya Svinkina; Dirk Heckl; Eamon Comer; Xiaoyu Li; Christie Ciarlo; Emily Hartman; Nikhil Munshi; Monica Schenone; Stuart L Schreiber; Steven A Carr; Benjamin L Ebert
Journal:  Science       Date:  2013-11-29       Impact factor: 47.728

6.  Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.

Authors:  Philip P Chamberlain; Antonia Lopez-Girona; Karen Miller; Gilles Carmel; Barbra Pagarigan; Barbara Chie-Leon; Emily Rychak; Laura G Corral; Yan J Ren; Maria Wang; Mariko Riley; Silvia L Delker; Takumi Ito; Hideki Ando; Tomoyuki Mori; Yoshinori Hirano; Hiroshi Handa; Toshio Hakoshima; Thomas O Daniel; Brian E Cathers
Journal:  Nat Struct Mol Biol       Date:  2014-08-10       Impact factor: 15.369

Review 7.  Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system.

Authors:  Dennis L Buckley; Craig M Crews
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-23       Impact factor: 16.823

8.  Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

Authors:  Michael Zengerle; Kwok-Ho Chan; Alessio Ciulli
Journal:  ACS Chem Biol       Date:  2015-06-16       Impact factor: 5.100

9.  Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.

Authors:  Eric S Fischer; Kerstin Böhm; John R Lydeard; Haidi Yang; Michael B Stadler; Simone Cavadini; Jane Nagel; Fabrizio Serluca; Vincent Acker; Gondichatnahalli M Lingaraju; Ritesh B Tichkule; Michael Schebesta; William C Forrester; Markus Schirle; Ulrich Hassiepen; Johannes Ottl; Marc Hild; Rohan E J Beckwith; J Wade Harper; Jeremy L Jenkins; Nicolas H Thomä
Journal:  Nature       Date:  2014-07-16       Impact factor: 49.962

10.  The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.

Authors:  Gang Lu; Richard E Middleton; Huahang Sun; MarkVic Naniong; Christopher J Ott; Constantine S Mitsiades; Kwok-Kin Wong; James E Bradner; William G Kaelin
Journal:  Science       Date:  2013-11-29       Impact factor: 47.728
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  47 in total

1.  Corrigendum: Protein degradation: Prime time for PROTACs.

Authors:  Raymond J Deshaies
Journal:  Nat Chem Biol       Date:  2015-11       Impact factor: 15.040

Review 2.  Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.

Authors:  Rachel J Harding; Yu-Feng Tong
Journal:  Acta Pharmacol Sin       Date:  2018-04-05       Impact factor: 6.150

3.  PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer.

Authors:  Kanak Raina; Jing Lu; Yimin Qian; Martha Altieri; Deborah Gordon; Ann Marie K Rossi; Jing Wang; Xin Chen; Hanqing Dong; Kam Siu; James D Winkler; Andrew P Crew; Craig M Crews; Kevin G Coleman
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-06       Impact factor: 11.205

Review 4.  PROTACs: great opportunities for academia and industry.

Authors:  Xiuyun Sun; Hongying Gao; Yiqing Yang; Ming He; Yue Wu; Yugang Song; Yan Tong; Yu Rao
Journal:  Signal Transduct Target Ther       Date:  2019-12-24

5.  The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.

Authors:  Taishi Yonezawa; Hirotaka Takahashi; Shiori Shikata; Xiaoxiao Liu; Moe Tamura; Shuhei Asada; Tsuyoshi Fukushima; Tomofusa Fukuyama; Yosuke Tanaka; Tatsuya Sawasaki; Toshio Kitamura; Susumu Goyama
Journal:  J Biol Chem       Date:  2017-05-23       Impact factor: 5.157

Review 6.  Proteolysis-targeting chimeras in drug development: A safety perspective.

Authors:  Kevin Moreau; Muireann Coen; Andrew X Zhang; Fiona Pachl; M Paola Castaldi; Goran Dahl; Helen Boyd; Clay Scott; Pete Newham
Journal:  Br J Pharmacol       Date:  2020-02-25       Impact factor: 8.739

Review 7.  Induced protein degradation: an emerging drug discovery paradigm.

Authors:  Ashton C Lai; Craig M Crews
Journal:  Nat Rev Drug Discov       Date:  2016-11-25       Impact factor: 84.694

Review 8.  Targeting Brd4 for cancer therapy: inhibitors and degraders.

Authors:  Yingchao Duan; Yuanyuan Guan; Wenping Qin; Xiaoyu Zhai; Bin Yu; Hongmin Liu
Journal:  Medchemcomm       Date:  2018-08-07       Impact factor: 3.597

9.  Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity.

Authors:  Zongyang Lv; Katelyn M Williams; Lingmin Yuan; James H Atkison; Shaun K Olsen
Journal:  J Biol Chem       Date:  2018-10-02       Impact factor: 5.157

10.  FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor.

Authors:  Leili Ran; Yuedan Chen; Jessica Sher; Elissa W P Wong; Devan Murphy; Jenny Q Zhang; Dan Li; Kemal Deniz; Inna Sirota; Zhen Cao; Shangqian Wang; Youxin Guan; Shipra Shukla; Katie Yang Li; Alan Chramiec; Yuanyuan Xie; Deyou Zheng; Richard P Koche; Cristina R Antonescu; Yu Chen; Ping Chi
Journal:  Cancer Discov       Date:  2017-11-21       Impact factor: 39.397
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