Jung Hyun Kwon1, Seung Eun Lee1, Hye Ah Lee2, Young Ju Kim3, Hwa Young Lee4, Hye Sun Gwak5, Eun Ae Park1, Su Jin Cho1, Se Young Oh6, Eun Hee Ha2, Hyesook Park7, Hae Soon Kim8. 1. Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea. 2. Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea. 3. Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Korea. 4. Department of Anatomy, School of Medicine, Ewha Womans University, Seoul, Korea. 5. College of Pharmacy, Ewha Womans University, Seoul, Korea. 6. Department of Food and Nutrition, Kyung Hee University, Seoul, Korea. 7. Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea. Electronic address: hpark@ewha.ac.kr. 8. Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea. Electronic address: hyesk@ewha.ac.kr.
Abstract
OBJECTIVE: The relationship between 25-hydroxyvitamin D (25[OH]D) levels and the lipid and metabolic levels of the prepubertal normal population is unclear. Our goals were to investigate the association of serum 25(OH)D concentrations with lipid and metabolic levels in Korean prepubertal children ages 7-9 y. METHODS: We followed 205 children, ages 7-9 y in the Ewha Birth and Growth Cohort study, a prospective cohort sample established in 2001-2006, from July to August 2011. We studied the association of serum 25-hydroxyvitamin D (25[OH]D) levels with components of metabolic syndrome and insulin resistance indices using multivariate regression analysis adjusted for body mass index (BMI) z-scores. RESULTS: The mean age of the 205 subjects was 7.89 ± 0.85 y, and the sample included 109 boys (53.2%). The average 25(OH)D levels of all participants was 25.0 ± 5.4 ng/mL. After adjustment for age and sex, triacylglycerol levels were significantly associated with 25(OH)D (β = -0.02, P = 0.02) concentrations even after adjustment for BMI z-scores (β = -0.02, P = 0.04). However, other metabolic components were not correlated with 25(OH)D status. Those with the lowest quartile of 25(OH)D levels had the highest serum triacylglycerol levels (P = 0.04, Ptrend = 0.01). CONCLUSIONS: We found that serum 25(OH)D levels were negatively associated with serum triacylglycerol levels, even independently of adiposity, in prepubertal children. This study suggests that 25(OH)D insufficiency is related to metabolic syndrome via the derangement of triacylglycerol metabolism.
OBJECTIVE: The relationship between 25-hydroxyvitamin D (25[OH]D) levels and the lipid and metabolic levels of the prepubertal normal population is unclear. Our goals were to investigate the association of serum 25(OH)D concentrations with lipid and metabolic levels in Korean prepubertal children ages 7-9 y. METHODS: We followed 205 children, ages 7-9 y in the Ewha Birth and Growth Cohort study, a prospective cohort sample established in 2001-2006, from July to August 2011. We studied the association of serum 25-hydroxyvitamin D (25[OH]D) levels with components of metabolic syndrome and insulin resistance indices using multivariate regression analysis adjusted for body mass index (BMI) z-scores. RESULTS: The mean age of the 205 subjects was 7.89 ± 0.85 y, and the sample included 109 boys (53.2%). The average 25(OH)D levels of all participants was 25.0 ± 5.4 ng/mL. After adjustment for age and sex, triacylglycerol levels were significantly associated with 25(OH)D (β = -0.02, P = 0.02) concentrations even after adjustment for BMI z-scores (β = -0.02, P = 0.04). However, other metabolic components were not correlated with 25(OH)D status. Those with the lowest quartile of 25(OH)D levels had the highest serum triacylglycerol levels (P = 0.04, Ptrend = 0.01). CONCLUSIONS: We found that serum 25(OH)D levels were negatively associated with serum triacylglycerol levels, even independently of adiposity, in prepubertal children. This study suggests that 25(OH)Dinsufficiency is related to metabolic syndrome via the derangement of triacylglycerol metabolism.