Elena García-Martín1,2,3, Carmen Martínez2,4, Mercedes Serrador5, Hortensia Alonso-Navarro6,7, Francisco Navacerrada6,8, Esteban García-Albea7, José A G Agúndez1,2,3, Félix Javier Jiménez-Jiménez6,7. 1. Department of Pharmacology, University of Extremadura, Cáceres, Spain. 2. Red de Investigación de Reacciones Adversas a Alergenos y Fármacos, Instituto de Salud Carlos III, Madrid, Spain. 3. AMGenomics, Cáceres, Spain. 4. Department of Pharmacology, University of Extremadura, Badajoz, Spain. 5. Department of Family Medicine, Hospital "Príncipe de Asturias,", Universidad de Alcalá, Madrid, Spain. 6. Section of Neurology, Hospital Universitario del Sureste, Madrid, Spain. 7. Department of Medicine-Neurology, Hospital "Príncipe de Asturias,", Universidad de Alcalá, Madrid, Spain. 8. Service of Neurology, Hospital "Ramón y Cajal,", Universidad de Alcalá, Madrid, Spain.
Abstract
BACKGROUND/ OBJECTIVES: Many biochemical, pharmacological, neuropathological, and experimental data suggest a possible role of nitric oxide in the pathogenesis of migraine. We investigated the possible association between functional single nucleotide polymorphisms (SNPs) in the neuronal nitric oxide synthase gene (NOS1 or nNOS; chromosome 12q24.22) and the risk for migraine. METHODS: We studied the frequency of the of rs7977109 and rs693534 genotypes and allelic variants in 197 patients with migraine and 308 healthy controls using a TaqMan-based qPCR assay. As a secondary analysis, we studied the possible influence of gender, age at onset of migraine, positive family history of migraine, and presence or absence of aura on the genotypes frequency. RESULTS: The frequencies of rs7977109 and rs693534 genotypes and allelic variants were not associated with the risk for migraine with OR for minor alleles = 0.94 (95% CI 0.72-1.23) and = 0.88 (0.68-1.15), respectively, and the lack of association was not influenced by gender, age at onset of migraine, positive family history of migraine, and presence or absence of aura. CONCLUSION: NOS1 rs7977109 and rs693534 genotypes and allelic variants are not associated with the risk for migraine in Caucasian Spanish people.
BACKGROUND/ OBJECTIVES: Many biochemical, pharmacological, neuropathological, and experimental data suggest a possible role of nitric oxide in the pathogenesis of migraine. We investigated the possible association between functional single nucleotide polymorphisms (SNPs) in the neuronal nitric oxide synthase gene (NOS1 or nNOS; chromosome 12q24.22) and the risk for migraine. METHODS: We studied the frequency of the of rs7977109 and rs693534 genotypes and allelic variants in 197 patients with migraine and 308 healthy controls using a TaqMan-based qPCR assay. As a secondary analysis, we studied the possible influence of gender, age at onset of migraine, positive family history of migraine, and presence or absence of aura on the genotypes frequency. RESULTS: The frequencies of rs7977109 and rs693534 genotypes and allelic variants were not associated with the risk for migraine with OR for minor alleles = 0.94 (95% CI 0.72-1.23) and = 0.88 (0.68-1.15), respectively, and the lack of association was not influenced by gender, age at onset of migraine, positive family history of migraine, and presence or absence of aura. CONCLUSION:NOS1rs7977109 and rs693534 genotypes and allelic variants are not associated with the risk for migraine in Caucasian Spanish people.
Authors: Elena García-Martín; Gara Esguevillas; Mercedes Serrador; Hortensia Alonso-Navarro; Francisco Navacerrada; Gemma Amo; Esteban García-Albea; José A G Agúndez; Félix Javier Jiménez-Jiménez Journal: J Neural Transm (Vienna) Date: 2018-01-03 Impact factor: 3.575
Authors: Elena García-Martín; Santiago Navarro-Muñoz; Christopher Rodriguez; Mercedes Serrador; Hortensia Alonso-Navarro; Marisol Calleja; Laura Turpín-Fenoll; Marta Recio-Bermejo; Rafael García-Ruiz; Jorge Millán-Pascual; Francisco Navacerrada; José Francisco Plaza-Nieto; Esteban García-Albea; José A G Agúndez; Félix Javier Jiménez-Jiménez Journal: Pharmacogenomics J Date: 2019-12-03 Impact factor: 3.550
Authors: Caroline Ran; Julia M Michalska; Carmen Fourier; Christina Sjöstrand; Elisabet Waldenlind; Anna Steinberg; Andrea C Belin Journal: Brain Sci Date: 2020-12-31