| Literature DB >> 26283027 |
Yuan Lin1, Xuejiang Guo2, Bijun Zhao3, Juanjuan Liu2, Min Da4, Yang Wen1, Yuanli Hu4, Bixian Ni1, Kai Zhang1, Shiwei Yang5, Jing Xu6, Juncheng Dai7, Xiaowei Wang6, Yankai Xia8, Hongxia Ma7, Guangfu Jin7, Shiqiang Yu3, Jiayin Liu9, Bernard D Keavney10, Judith A Goodship11, Heather J Cordell11, Xinru Wang8, Hongbing Shen1, Jiahao Sha2, Zuomin Zhou2, Yijiang Chen6, Xuming Mo4, Lingfei Luo12, Zhibin Hu1.
Abstract
Our previous genome-wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) in Han Chinese. Here we identify additional loci by testing promising associations in an extended 3-stage validation consisting of 6,053 CHD cases and 7,410 controls. We find GW significant (P<5.0 × 10(-8)) evidence of 4 additional CHD susceptibility loci at 4q31.22 (rs1400558, upstream of EDNRA, Pall=1.63 × 10(-9)), 9p24.2 (rs7863990, close to SMARCA2, Pall=3.71 × 10(-14)), 12q24.13 (rs2433752, upstream of TBX3 and TBX5, Pall=1.04 × 10(-10)) and 20q12 (rs490514, in PTPRT, Pall=1.20 × 10(-13)). Moreover, the data from previous European GWAS supports that rs490514 is associated with the risk of CHD (P=3.40 × 10(-3)). These results enhance our understanding of CHD susceptibility.Entities:
Mesh：
Year: 2015 PMID： 26283027 DOI： 10.1038/ncomms9082
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919