| Literature DB >> 26283008 |
Merve Bayram1, Kathleen Deeley2, Maria F Reis3, Vanessa M Trombetta2, Timothy D Ruff2, Regina C Sencak2, Michael Hummel2, Piper M Dizak2, Kelly Washam2, Helena F Romanos4, Andrea Lips3, Gutemberg Alves3, Marcelo C Costa4, José M Granjeiro5, Leonardo S Antunes3, Erika C Küchler2,3, Figen Seymen6, Alexandre R Vieira2.
Abstract
Clinically, primary and permanent teeth are distinct anatomically and the presentation of caries lesions differs between the two dentitions. Hence, the possibility exists that genetic contributions to tooth formation of the two dentitions are different. The purpose of this study was to test the hypothesis that genetic associations with an artificial caries model will not be the same between primary and permanent dentitions. Enamel samples from primary and permanent teeth were tested for microhardness at baseline, after carious lesion creation, and after fluoride application to verify association with genetic variants of selected genes. Associations were found between genetic variants of ameloblastin, amelogenin, enamelin, tuftelin, tuftelin interactive protein 11, and matrix metallopeptidase 20 and enamel from permanent teeth but not with enamel from primary teeth. In conclusion, our data continue to support that genetic variation may impact enamel development and consequently individual caries susceptibility. These effects may be distinct between primary and permanent dentitions.Entities:
Keywords: dental caries; dentition; enamel microhardness; permanent; primary
Year: 2015 PMID： 26283008 PMCID： PMC4758910 DOI： 10.1111/eos.12204
Source DB: PubMed Journal: Eur J Oral Sci ISSN： 0909-8836 Impact factor: 2.612