Monica Currò1, Debora Di Mauro2, Daniele Bruschetta3, Federico D'Amico4, Mercurio Vecchio5, Fabio Trimarchi6, Riccardo Ientile7, Daniela Caccamo8. 1. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Building G, Biological Tower, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: monica.curro@unime.it. 2. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Building G, Biological Tower, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: ddimauro@unime.it. 3. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Building G, Biological Tower, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: daniele.bruschetta@unime.it. 4. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Building G, Biological Tower, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: fededamico92@gmail.com. 5. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Building G, Biological Tower, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: mercuriovecchio@gmail.com. 6. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Building G, Biological Tower, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: fatrim@unime.it. 7. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Building G, Biological Tower, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: ientile@unime.it. 8. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Building G, Biological Tower, Via C. Valeria 1, 98125 Messina, Italy. Electronic address: dcaccamo@unime.it.
Abstract
OBJECTIVES: To investigate the distribution of MTHFR C677T and A1298C as well as PON1 Q192R gene polymorphisms, known to be involved in hyperhomocysteinemia-related cardiovascular risk, in elite athletes. DESIGN AND METHODS: Genetic background at MTHFR and PON1 loci and plasma levels of homocysteine, folate, vitamin B12 and advanced oxidation protein product (AOPP) levels were assessed in thirty-seven 400m male hurdlers and thirty-four sedentary subjects. RESULTS: Homocysteine plasma levels and AOPPs were significantly higher in hurdlers bearing the TT677/AA1298 diplotype than in both hurdlers and sedentary subjects with other diplotypes. A positive dependence between either homocysteine or AOPP plasma levels and MTHFR, but not PON1 genotype, was observed in hurdlers. CONCLUSIONS: Elite hurdlers, having an unfavorable MTHFR genotype are exposed to increased cardiovascular risk, dependent on alterations of homocysteine and AOPP plasma levels.
OBJECTIVES: To investigate the distribution of MTHFRC677T and A1298C as well as PON1Q192R gene polymorphisms, known to be involved in hyperhomocysteinemia-related cardiovascular risk, in elite athletes. DESIGN AND METHODS: Genetic background at MTHFR and PON1 loci and plasma levels of homocysteine, folate, vitamin B12 and advanced oxidation protein product (AOPP) levels were assessed in thirty-seven 400m male hurdlers and thirty-four sedentary subjects. RESULTS:Homocysteine plasma levels and AOPPs were significantly higher in hurdlers bearing the TT677/AA1298 diplotype than in both hurdlers and sedentary subjects with other diplotypes. A positive dependence between either homocysteine or AOPP plasma levels and MTHFR, but not PON1 genotype, was observed in hurdlers. CONCLUSIONS: Elite hurdlers, having an unfavorable MTHFR genotype are exposed to increased cardiovascular risk, dependent on alterations of homocysteine and AOPP plasma levels.