Maciej Romanowski1, Violetta Dziedziejko2, Agnieszka Maciejewska-Karlowska3, Marek Sawczuk3, Krzysztof Safranow2, Leszek Domanski4, Andrzej Pawlik5. 1. Department of General & Transplantation Surgery, Pomeranian Medical University, Szczecin, Poland. 2. Department of Biochemistry & Medical Chemistry, Pomeranian Medical University, Szczecin, Poland. 3. Faculty of Physical Education & Health Promotion, University of Szczecin, Szczecin, Poland. 4. Clinical Department of Nephrology, Transplantology & Internal Medicine, Pomeranian Medical University, Szczecin, Poland. 5. Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
Abstract
BACKGROUND: Post-transplant diabetes mellitus (PTDM) is a common metabolic complication after organ transplantation and may be associated with the use of calcineurin inhibitors (tacrolimus and cyclosporine). Leptin and adiponectin are adipokines and play an important role in the regulation of insulin secretion as well as glucose and lipid metabolism. AIM: The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and development of PTDM. MATERIALS & METHODS: The study included 323 patients who received kidney transplants and were treated with calcineurin inhibitors (tacrolimus or cyclosporine). RESULTS: The association between adiponectin and leptin gene polymorphisms and PTDM was studied in three models of Cox regression analysis--additive, dominant and recessive. In these three models, the LEP rs2167270 gene polymorphism was statistically significantly associated with increased risk of PTDM. The association between the LEP rs2167270 polymorphism and PTDM was confirmed by multivariate regression analysis. CONCLUSION: The results of our study suggest an association between the leptin rs2167270 gene A allele and PTDM. Original submitted 27 February 2015; Revision submitted 22 May 2015.
BACKGROUND: Post-transplant diabetes mellitus (PTDM) is a common metabolic complication after organ transplantation and may be associated with the use of calcineurin inhibitors (tacrolimus and cyclosporine). Leptin and adiponectin are adipokines and play an important role in the regulation of insulin secretion as well as glucose and lipid metabolism. AIM: The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and development of PTDM. MATERIALS & METHODS: The study included 323 patients who received kidney transplants and were treated with calcineurin inhibitors (tacrolimus or cyclosporine). RESULTS: The association between adiponectin and leptin gene polymorphisms and PTDM was studied in three models of Cox regression analysis--additive, dominant and recessive. In these three models, the LEPrs2167270 gene polymorphism was statistically significantly associated with increased risk of PTDM. The association between the LEPrs2167270 polymorphism and PTDM was confirmed by multivariate regression analysis. CONCLUSION: The results of our study suggest an association between the leptinrs2167270 gene A allele and PTDM. Original submitted 27 February 2015; Revision submitted 22 May 2015.
Authors: William S Oetting; Baolin Wu; David P Schladt; Weihua Guan; Jessica van Setten; Brendan J Keating; David Iklé; Rory P Remmel; Casey R Dorr; Roslyn B Mannon; Arthur J Matas; Ajay K Israni; Pamala A Jacobson Journal: Transplantation Date: 2019-06 Impact factor: 4.939
Authors: Jacek Rysz; Beata Franczyk; Maciej Radek; Aleksandra Ciałkowska-Rysz; Anna Gluba-Brzózka Journal: Int J Mol Sci Date: 2021-03-26 Impact factor: 5.923