Pingda Bian1, Xiuyang Li2, Qifeng Ying3, Jinping Chen3, Xue Jin4, Jiong Yao5, Zhangxuan Shou6. 1. Center for Diagnosis and Treatment of Osteoporosis, Zhejiang Provincial People's Hospital, Hangzhou, China. Electronic address: bianpingda@hotmail.com. 2. Department of Epidemiology & Health Statistics, Zhejiang University, Hangzhou, China. 3. Center for Diagnosis and Treatment of Osteoporosis, Zhejiang Provincial People's Hospital, Hangzhou, China. 4. Department of Pharmaceutical Science, Zhejiang Provincial People's Hospital, Hangzhou, China. 5. Department of Medical Records and Statistics, Zhejiang Provincial People's Hospital, Hangzhou, China. 6. Department of Pharmaceutical Science, Zhejiang Provincial People's Hospital, Hangzhou, China. Electronic address: shousor@126.com.
Abstract
OBJECTIVE: This study was designed to identify factors associated with the femoral neck bone mineral density (FNBMD) of the very elderly (aged 80 or more) Chinese males. METHODS: A total of 1177 very elderly Chinese males were recruited into the study, and subjected to FNBMD, biochemical parameters, bone turnover markers, and serum sex steroids assays. Univariate and multivariate regression analyses were performed to identify factors independently related to FNBMD. RESULTS: It was demonstrated that age (β=-0.003, P=0.035), concomitant chronic obstructive pulmonary disease (COPD, β=-0.027, P=0.009), serum β-C-telopeptide of type 1 collagen (β-CTX, β=-0.097, P<0.001), and parathyroid hormone (PTH, β=-0.001, P=0.004) were negatively correlated with the FNBMD, while body mass index (BMI, β=0.009, P<0.001), and serum estradiol (β=0.001, P=0.038) were positively related to FNBMD in very elderly Chinese males. CONCLUSION: An integrated intervention should be implemented to increase the BMD of the very elderly males, with special attention to preventing and curing COPD, reducing serum β-CTX and PTH levels, as well as keeping a proper BMI and serum estradiol level.
OBJECTIVE: This study was designed to identify factors associated with the femoral neck bone mineral density (FNBMD) of the very elderly (aged 80 or more) Chinese males. METHODS: A total of 1177 very elderly Chinese males were recruited into the study, and subjected to FNBMD, biochemical parameters, bone turnover markers, and serum sex steroids assays. Univariate and multivariate regression analyses were performed to identify factors independently related to FNBMD. RESULTS: It was demonstrated that age (β=-0.003, P=0.035), concomitant chronic obstructive pulmonary disease (COPD, β=-0.027, P=0.009), serum β-C-telopeptide of type 1 collagen (β-CTX, β=-0.097, P<0.001), and parathyroid hormone (PTH, β=-0.001, P=0.004) were negatively correlated with the FNBMD, while body mass index (BMI, β=0.009, P<0.001), and serum estradiol (β=0.001, P=0.038) were positively related to FNBMD in very elderly Chinese males. CONCLUSION: An integrated intervention should be implemented to increase the BMD of the very elderly males, with special attention to preventing and curing COPD, reducing serum β-CTX and PTH levels, as well as keeping a proper BMI and serum estradiol level.
Authors: Guilherme Carlos Brech; Jessica Sillas DE Freitas; Marcia Gouvea; Adriana Machado-Lima; Marta Ferreira Bastos; Liliam Takayama; Rosa Maria Rodrigues Pereira; Julia Maria D'Andréa Greve; Angelica Castilho Alonso Journal: Acta Ortop Bras Date: 2021 Mar-Apr Impact factor: 0.513