Literature DB >> 26277912

Copper(I)-Catalyzed Radical Addition of Acetophenones to Alkynes in Furan Synthesis.

Srimanta Manna1,2, Andrey P Antonchick1,2.   

Abstract

A synthesis of multisubstituted furans from readily available acetophenones and electron-deficient alkynes via direct C(sp(3))-H bond functionalization under radical reaction conditions is described. The developed transformation is catalyzed by copper(I) salts using di-tert-butyl peroxide as an external oxidant. This method offers an efficient access to biologically important scaffolds from simple compounds.

Entities:  

Year:  2015        PMID： 26277912     DOI： 10.1021/acs.orglett.5b02114

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

Review 1.  Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.

Authors:  Imtiaz Khan; Aliya Ibrar; Sumera Zaib
Journal:  Top Curr Chem (Cham)       Date:  2021-01-05

2.  Regiospecific synthesis of polysubstituted furans with mono- to tricarboxylates from various sulfonium acylmethylides and acetylenic esters.

Authors:  Jun Dong; Hongguang Du; Jiaxi Xu
Journal:  RSC Adv       Date:  2019-08-12       Impact factor: 3.361

3.  [1+1+1] Cyclotrimerization for the Synthesis of Cyclopropanes.

Authors:  Srimanta Manna; Andrey P Antonchick
Journal:  Angew Chem Int Ed Engl       Date:  2016-03-21       Impact factor: 15.336

4.  Photocatalytic synthesis of tetra-substituted furans promoted by carbon dioxide.

Authors:  Ya-Ming Tian; Huaiju Wang; Burkhard König
Journal:  Chem Sci       Date:  2021-12-06       Impact factor: 9.825
  4 in total

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