BACKGROUND/AIMS: Factors in congenital adrenal hyperplasia (CAH) that may affect quality of life (QOL) include the need for lifelong medication, the risk of adrenal crisis, and hyperandrogenic symptoms. The objectives were to evaluate health-related QOL (HRQOL) in children with CAH, and whether CAH poses an additional burden compared to other endocrine disorders. METHODS: The validated PedsQL 4.0 generic core scales were administered to subjects (8-18 years) with CAH and hypothyroidism and their parents. The minimal clinically important difference (MCID) was determined for each scale score, allowing a comparison with the healthy population. A score of >1 standard deviation below the population mean was considered at risk for impaired HRQOL. RESULTS: In CAH, the mean total HRQOL scores were >1 MCID below the population mean, and a higher percentage than expected had scores considered at risk. CONCLUSION: Compared to subjects with hypothyroidism, subjects with CAH self-reported lower school domain scores. CAH subjects more frequently reported peers not wanting to be friends.
BACKGROUND/AIMS: Factors in congenital adrenal hyperplasia (CAH) that may affect quality of life (QOL) include the need for lifelong medication, the risk of adrenal crisis, and hyperandrogenic symptoms. The objectives were to evaluate health-related QOL (HRQOL) in children with CAH, and whether CAH poses an additional burden compared to other endocrine disorders. METHODS: The validated PedsQL 4.0 generic core scales were administered to subjects (8-18 years) with CAH and hypothyroidism and their parents. The minimal clinically important difference (MCID) was determined for each scale score, allowing a comparison with the healthy population. A score of >1 standard deviation below the population mean was considered at risk for impaired HRQOL. RESULTS: In CAH, the mean total HRQOL scores were >1 MCID below the population mean, and a higher percentage than expected had scores considered at risk. CONCLUSION: Compared to subjects with hypothyroidism, subjects with CAH self-reported lower school domain scores. CAH subjects more frequently reported peers not wanting to be friends.
Authors: Stefan Pilz; Michael Krebs; Walter Bonfig; Wolfgang Högler; Anna Hochgerner; Greisa Vila; Christian Trummer; Verena Theiler-Schwetz; Barbara Obermayer-Pietsch; Peter Wolf; Thomas Scherer; Florian Kiefer; Elke Fröhlich-Reiterer; Elena Gottardi-Butturini; Klaus Kapelari; Stefan Schatzl; Susanne Kaser; Günter Höfle; Dietmar Schiller; Vinzenz Stepan; Anton Luger; Stefan Riedl Journal: J Klin Endokrinol Stoffwechs Date: 2022-03-02
Authors: Lea Tschaidse; Marcus Quinkler; Hedi Claahsen-van der Grinten; Anna Nordenström; Aude De Brac de la Perriere; Matthias K Auer; Nicole Reisch Journal: J Clin Med Date: 2022-08-02 Impact factor: 4.964
Authors: Alyssa Halper; Mary C Hooke; Maria Teresa Gonzalez-Bolanos; Nancy Vanderburg; Thang N Tran; Jane Torkelson; Kyriakie Sarafoglou Journal: Health Qual Life Outcomes Date: 2017-10-06 Impact factor: 3.186