Chen-Yi Wu1,2,3,4, Hsiao-Yun Hu2,3,5, Yiing-Jenq Chou2,3, Nicole Huang5,6, Yi-Chang Chou2,3,5, Meng-Sui Lee4,7, Chung-Pin Li7,8. 1. Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan. 2. Institute of Public Health, National Yang Ming University, Taipei, Taiwan. 3. Department of Public Health, National Yang Ming University, Taipei, Taiwan. 4. Department of Dermatology, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan. 5. Department of Education and Research, Taipei City Hospital, Taipei, Taiwan. 6. Institute of Hospital and Health Care Administration, National Yang Ming University, Taipei, Taiwan. 7. National Yang Ming University School of Medicine, Taipei, Taiwan. 8. Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Abstract
OBJECTIVES: To estimate the all-cause, cardiovascular, and cancer mortality risks associated with serum uric acid levels in elderly adults. DESIGN: Cohort study. SETTING: The Annual Geriatric Health Examination Program database from 2006 to 2010. PATICIPANTS: Community-dwelling Taipei citizens aged 65 and older (N = 77,541). MEASUREMENTS: Stratified according to sex, serum uric acid levels were analyzed in quartiles and as normal versus high categories. Mortality was determined by matching cohort identifications with national death files. RESULTS: Men had significantly higher uric acid levels than women (P < .001), and mean levels increased with age (P < .001). Serum uric acid levels (normal vs high) were an independent risk factor for all-cause and cardiovascular mortality in men and women, with the strongest association found for cardiovascular mortality. The association between serum uric acid levels and cardiovascular mortality was independent of other cardiovascular risk factors such as hypertension, diabetes mellitus, hyperlipidemia, and glomerular filtration rate levels. When levels were analyzed as quartiles, men with levels in the second quartile had the lowest hazard ratios for all-cause and cardiovascular mortality. CONCLUSION: High serum uric acid levels are associated with greater risk of all-cause and cardiovascular mortality but not cancer mortality in elderly adults. Further studies are warranted to investigate the prognostic implications and potential utility in the monitoring of therapy.
OBJECTIVES: To estimate the all-cause, cardiovascular, and cancer mortality risks associated with serum uric acid levels in elderly adults. DESIGN: Cohort study. SETTING: The Annual Geriatric Health Examination Program database from 2006 to 2010. PATICIPANTS: Community-dwelling Taipei citizens aged 65 and older (N = 77,541). MEASUREMENTS: Stratified according to sex, serum uric acid levels were analyzed in quartiles and as normal versus high categories. Mortality was determined by matching cohort identifications with national death files. RESULTS: Men had significantly higher uric acid levels than women (P < .001), and mean levels increased with age (P < .001). Serum uric acid levels (normal vs high) were an independent risk factor for all-cause and cardiovascular mortality in men and women, with the strongest association found for cardiovascular mortality. The association between serum uric acid levels and cardiovascular mortality was independent of other cardiovascular risk factors such as hypertension, diabetes mellitus, hyperlipidemia, and glomerular filtration rate levels. When levels were analyzed as quartiles, men with levels in the second quartile had the lowest hazard ratios for all-cause and cardiovascular mortality. CONCLUSION: High serum uric acid levels are associated with greater risk of all-cause and cardiovascular mortality but not cancer mortality in elderly adults. Further studies are warranted to investigate the prognostic implications and potential utility in the monitoring of therapy.
Authors: Gloria Brombo; Francesco Bonetti; Stefano Volpato; Mario L Morieri; Ettore Napoli; Stefania Bandinelli; Antonio Cherubini; Marcello Maggio; Jack Guralnik; Luigi Ferrucci; Giovanni Zuliani Journal: Nutr Metab Cardiovasc Dis Date: 2019-06-28 Impact factor: 4.222
Authors: Jui-Hua Huang; Ren-Hau Li; Shu-Ling Huang; Hon-Ke Sia; Chao-Hung Yu; Feng-Cheng Tang Journal: Int J Environ Res Public Health Date: 2021-07-02 Impact factor: 3.390