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Literature DB >> 26276627

Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics.

Erez Lieberman Aiden¹, Rafael Casellas².

Abstract

We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 26276627 PMCID： PMC4537798 DOI： 10.1016/j.cell.2015.07.034

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

21 in total

1. Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

Authors: Ali A Zarrin; Catherine Del Vecchio; Eva Tseng; Megan Gleason; Payam Zarin; Ming Tian; Frederick W Alt
Journal: Science Date: 2006-12-14 Impact factor: 47.728

2. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.

Authors: Ofir Hakim; Wolfgang Resch; Arito Yamane; Isaac Klein; Kyong-Rim Kieffer-Kwon; Mila Jankovic; Thiago Oliveira; Anne Bothmer; Ty C Voss; Camilo Ansarah-Sobrinho; Ewy Mathe; Genqing Liang; Jesse Cobell; Hirotaka Nakahashi; Davide F Robbiani; Andre Nussenzweig; Gordon L Hager; Michel C Nussenzweig; Rafael Casellas
Journal: Nature Date: 2012-02-07 Impact factor: 49.962

Review 3. Inter-chromosomal gene regulation in the mammalian cell nucleus.

Authors: Wouter de Laat; Frank Grosveld
Journal: Curr Opin Genet Dev Date: 2007-09-20 Impact factor: 5.578

4. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.

Authors: Sherry G Lin; Chunguang Guo; Arthur Su; Yu Zhang; Frederick W Alt
Journal: Proc Natl Acad Sci U S A Date: 2015-01-26 Impact factor: 11.205

5. Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation.

Authors: Alexander L Kovalchuk; Camilo Ansarah-Sobrinho; Ofir Hakim; Wolfgang Resch; Helena Tolarová; Wendy Dubois; Arito Yamane; Makiko Takizawa; Isaac Klein; Gordon L Hager; Herbert C Morse; Michael Potter; Michel C Nussenzweig; Rafael Casellas
Journal: Proc Natl Acad Sci U S A Date: 2012-06-18 Impact factor: 11.205

6. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

Authors: Suhas S P Rao; Miriam H Huntley; Neva C Durand; Elena K Stamenova; Ivan D Bochkov; James T Robinson; Adrian L Sanborn; Ido Machol; Arina D Omer; Eric S Lander; Erez Lieberman Aiden
Journal: Cell Date: 2014-12-11 Impact factor: 41.582

7. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

Authors: Roberto Chiarle; Yu Zhang; Richard L Frock; Susanna M Lewis; Benoit Molinie; Yu-Jui Ho; Darienne R Myers; Vivian W Choi; Mara Compagno; Daniel J Malkin; Donna Neuberg; Stefano Monti; Cosmas C Giallourakis; Monica Gostissa; Frederick W Alt
Journal: Cell Date: 2011-09-30 Impact factor: 41.582

Review 8. Mechanisms of programmed DNA lesions and genomic instability in the immune system.

Authors: Frederick W Alt; Yu Zhang; Fei-Long Meng; Chunguang Guo; Bjoern Schwer
Journal: Cell Date: 2013-01-31 Impact factor: 41.582

9. AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.

Authors: Hillary Selle Gramlich; Tara Reisbig; David G Schatz
Journal: PLoS One Date: 2012-06-29 Impact factor: 3.240

10. Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.

Authors: Cameron S Osborne; Lyubomira Chakalova; Jennifer A Mitchell; Alice Horton; Andrew L Wood; Daniel J Bolland; Anne E Corcoran; Peter Fraser
Journal: PLoS Biol Date: 2007-08 Impact factor: 8.029

8 in total

1. The Energetics and Physiological Impact of Cohesin Extrusion.

Authors: Laura Vian; Aleksandra Pękowska; Suhas S P Rao; Kyong-Rim Kieffer-Kwon; Seolkyoung Jung; Laura Baranello; Su-Chen Huang; Laila El Khattabi; Marei Dose; Nathanael Pruett; Adrian L Sanborn; Andres Canela; Yaakov Maman; Anna Oksanen; Wolfgang Resch; Xingwang Li; Byoungkoo Lee; Alexander L Kovalchuk; Zhonghui Tang; Steevenson Nelson; Michele Di Pierro; Ryan R Cheng; Ido Machol; Brian Glenn St Hilaire; Neva C Durand; Muhammad S Shamim; Elena K Stamenova; José N Onuchic; Yijun Ruan; Andre Nussenzweig; David Levens; Erez Lieberman Aiden; Rafael Casellas
Journal: Cell Date: 2018-04-26 Impact factor: 41.582

Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics.

1. Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

2. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.

Review 3. Inter-chromosomal gene regulation in the mammalian cell nucleus.

4. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.

5. Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation.

6. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

7. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

Review 8. Mechanisms of programmed DNA lesions and genomic instability in the immune system.

9. AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.

10. Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.

1. The Energetics and Physiological Impact of Cohesin Extrusion.

Review 2. Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity.

Review 3. The role of chromatin loop extrusion in antibody diversification.

Review 4. Towards a predictive model of chromatin 3D organization.

Review 5. Genome organization in immune cells: unique challenges.

6. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning.

Review 7. The Secret Life of Chromosome Loops upon DNA Double-Strand Break.

Review 8. Long-Range Control of Class Switch Recombination by Transcriptional Regulatory Elements.