Literature DB >> 26276418

The pathophysiology of otosclerosis: Review of current research.

M Rudic1, I Keogh2, R Wagner3, E Wilkinson4, N Kiros5, E Ferrary6, O Sterkers6, A Bozorg Grayeli7, K Zarkovic8, N Zarkovic9.   

Abstract

Otosclerosis is a complex disease of the human otic capsule with highest incidence in adult Caucasians. So far, many possible etiological factors like genetics, HLA, autoimmunity, viruses, inflammation, and hormones have been investigated but still the development of the disease remains unclear. Currently, the surgical replacement of stapes (stapedotomy) remains the best possible treatment option. In this review, we analyze different etiological factors studied so far in otosclerosis pathophysiology and discuss most recent findings and possible new research pathways.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Hearing loss; Otosclerosis; Pathophysiology; Stapes

Mesh：

Substances：

Year:  2015        PMID： 26276418     DOI： 10.1016/j.heares.2015.07.014

Source DB:  PubMed          Journal:  Hear Res        ISSN： 0378-5955            Impact factor:   3.208


  18 in total

1.  The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.

Authors:  Chike Cao; Aaron B Oswald; Brian A Fabella; Yinshi Ren; Ramona Rodriguiz; George Trainor; Matthew B Greenblatt; Matthew J Hilton; Geoffrey S Pitt
Journal:  Bone       Date:  2019-05-20       Impact factor: 4.398

2.  Update From the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumours of the Ear.

Authors:  Lester D R Thompson
Journal:  Head Neck Pathol       Date:  2017-02-28

3.  Immune-Mediated Control of a Dormant Neurotropic RNA Virus Infection.

Authors:  Katelyn D Miller; Christine M Matullo; Katelynn A Milora; Riley M Williams; Kevin J O'Regan; Glenn F Rall
Journal:  J Virol       Date:  2019-08-28       Impact factor: 5.103

4.  Cochlear implantation among patients with otosclerosis: a systematic review of clinical characteristics and outcomes.

Authors:  Majed Assiri; Tawfiq Khurayzi; Afrah Alshalan; Abdulrahman Alsanosi
Journal:  Eur Arch Otorhinolaryngol       Date:  2021-08-17       Impact factor: 2.503

5.  Role of HRCT Temporal Bone in Predicting Surgical Difficulties Encountered in Fenestral Otosclerosis Surgery.

Authors:  Sandeep Govindan Prasad; Suma Radhakrishnan; E Devarajan; Rinu Susan Thomas; Lin Varghese
Journal:  Indian J Otolaryngol Head Neck Surg       Date:  2021-02-06

6.  Tinnitus and Otosclerosis: An Exploratory Study about the Prevalence, Features and Impact in Daily Life.

Authors:  Antonio Fontes Lima; Filipa Carvalho Moreira; Isabel Esteves Costa; Catia Azevedo; Fernando Mar; Luis Dias
Journal:  Int Arch Otorhinolaryngol       Date:  2021-11-03

7.  Prevalence of Internal Auditory Canal Diverticulum and Its Association with Hearing Loss and Otosclerosis.

Authors:  K J Pippin; T J Muelleman; J Hill; J Leever; H Staecker; L N Ledbetter
Journal:  AJNR Am J Neuroradiol       Date:  2017-10-05       Impact factor: 3.825

8.  The Stapes in Otosclerosis: Osteoarthritis of an Ear Ossicle.

Authors:  Anna-Lee Clarke-Brodber; Jerome B Taxy
Journal:  Head Neck Pathol       Date:  2021-01-07

9.  [Hormonal influence on hearing].

Authors:  J M Vahl; E Goldberg-Bockhorn; T K Hoffmann; M C Wigand
Journal:  HNO       Date:  2021-03-16       Impact factor: 1.284

10.  Rising Incidence of Sporadic Vestibular Schwannoma: True Biological Shift Versus Simply Greater Detection.

Authors:  John P Marinelli; Christine M Lohse; Brandon R Grossardt; John I Lane; Matthew L Carlson
Journal:  Otol Neurotol       Date:  2020-07       Impact factor: 2.619
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