Real Time Dual-Channel Multiplex SERS Ultradetection.

Surface-enhanced Raman scattering (SERS) can be combined with microfluidics for rapid multiplex analyte screening. Through combination of the high intensity and complex signals provided by SERS with the flow characteristics of microfluidic channels, we engineered a microdevice that is capable of monitoring various analytes from different sources in real time. Detection limits down to the nM range may allow the generation of a new family of devices for remote, real time monitoring of environmental samples such as natural or waste waters and application to the high-throughput screening of multiple samples in healthcare diagnostics.