Wangyong Zhu1, Fengchun Hu1, Tengda Zhao1, Cheng Wang2, Qian Tao3. 1. Resident, Department of Oral Maxillofacial-Head and Neck Oncology, Affiliated Hospital of Stomatology and Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. 2. Attending Physician and Associate Professor, Department of Oral Maxillofacial-Head and Neck Oncology, Affiliated Hospital of Stomatology and Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. 3. Attending Physician and Professor, Department of Oral Maxillofacial-Head and Neck Oncology, Affiliated Hospital of Stomatology and Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: taoqian@mail.sysu.edu.cn.
Abstract
PURPOSE: This retrospective study aimed to identify the clinical characteristics of radiation-induced sarcoma of the head and neck (RISHN) that could help in the early diagnosis of this rare disease. MATERIALS AND METHODS: From August 1995 through October 2014, 15 cases of RISHN presenting at the authors' department and 323 cases in the literature were reviewed. RESULTS: The incidence of RISHN was higher in men than in women (male-to-female ratio, 2.4:1). The mean latency was long (9.3 yr), and the tumor often occurred in middle age (50.0 yr old). Osteosarcoma was the predominant pathologic diagnosis (34.1%). The prognosis of RISHN was poor. CONCLUSION: RISHN is a serious long-term complication of radiotherapy and its incidence has been increasing in recent years. Owing to the long latency period, its early diagnosis is difficult to make. RISHN should be considered when a patient who has undergone radiotherapy presents with a mass, pain, or trismus in the irradiated field.
PURPOSE: This retrospective study aimed to identify the clinical characteristics of radiation-induced sarcoma of the head and neck (RISHN) that could help in the early diagnosis of this rare disease. MATERIALS AND METHODS: From August 1995 through October 2014, 15 cases of RISHN presenting at the authors' department and 323 cases in the literature were reviewed. RESULTS: The incidence of RISHN was higher in men than in women (male-to-female ratio, 2.4:1). The mean latency was long (9.3 yr), and the tumor often occurred in middle age (50.0 yr old). Osteosarcoma was the predominant pathologic diagnosis (34.1%). The prognosis of RISHN was poor. CONCLUSION: RISHN is a serious long-term complication of radiotherapy and its incidence has been increasing in recent years. Owing to the long latency period, its early diagnosis is difficult to make. RISHN should be considered when a patient who has undergone radiotherapy presents with a mass, pain, or trismus in the irradiated field.
Authors: Andrés Coca-Pelaz; Antti A Mäkitie; Primož Strojan; June Corry; Avraham Eisbruch; Jonathan J Beitler; Sandra Nuyts; Robert Smee; Johannes A Langendijk; William M Mendenhall; Cesare Piazza; Alessandra Rinaldo; Alfio Ferlito Journal: Adv Ther Date: 2020-11-13 Impact factor: 3.845