Literature DB >> 26275348

Effects of environmental enrichment during induction of methamphetamine dependence on the behavioral withdrawal symptoms in rats.

Samira Hajheidari1, Hossein Miladi-Gorji2, Imanollah Bigdeli3.   

Abstract

This study was designed to examine the effect of environmental enrichment during METH administration on the behavioral withdrawal symptoms after drug abstinence in rats. Rats reared in standard (SE) or enriched environment (EE) during induction of METH dependence with bi-daily injections of METH (2mg/kg, at 12-h. intervals) for 14 days. Then, rats were evaluated for behavioral withdrawal symptoms, and also for anxiety (elevated plus maze-EPM) and depression (Forced swim test-FST) over a ten day period of abstinence. The results showed that stereotypic behaviors score and the number of rearing were significantly lower in METH/EE rats compared to the SE group during 1-4 days. Also, The METH/EE group exhibited more weight gain during 6-10 days of abstinence. The METH/EE rats exhibited lower levels of immobility after METH abstinence than control group in the FST. EE had no effect on anxiety-like behavior. This study showed that exposure to EE diminished the severity of withdrawal symptoms and depressive-like behavior during spontaneous withdrawal from METH.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Anxiety; Behavioral withdrawal symptoms; Depression; Environmental enrichment; Methamphetamine dependence

Mesh：

Substances：

Year:  2015        PMID： 26275348     DOI： 10.1016/j.neulet.2015.08.010

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

1.  Intermittent Administration of Haloperidol after Cortical Impact Injury Neither Impedes Spontaneous Recovery Nor Attenuates the Efficacy of Environmental Enrichment.

Authors:  Gina C Bao; Isabel H Bleimeister; Lydia A Zimmerman; JoDy L Wellcome; Peter J Niesman; Hannah L Radabaugh; Corina O Bondi; Anthony E Kline
Journal:  J Neurotrauma       Date:  2019-01-09       Impact factor: 5.269

2.  Combining the Antipsychotic Drug Haloperidol and Environmental Enrichment after Traumatic Brain Injury Is a Double-Edged Sword.

Authors:  Kaitlin A Folweiler; Corina O Bondi; Elizabeth A Ogunsanya; Megan J LaPorte; Jacob B Leary; Hannah L Radabaugh; Christina M Monaco; Anthony E Kline
Journal:  J Neurotrauma       Date:  2016-04-20       Impact factor: 5.269

3.  Environmental and Pharmacological Manipulations Blunt the Stress Response of Zebrafish in a Similar Manner.

Authors:  Ana Cristina V V Giacomini; Murilo S Abreu; Rodrigo Zanandrea; Natália Saibt; Maria Tereza Friedrich; Gessi Koakoski; Darlan Gusso; Angelo L Piato; Leonardo J G Barcellos
Journal:  Sci Rep       Date:  2016-06-28       Impact factor: 4.379

4.  Environmental Enrichment Prevents Methamphetamine-Induced Spatial Memory Deficits and Obsessive-Compulsive Behavior in Rats.

Authors:  Samira Hajheidari; Hossein Miladi-Gorji; Imanollah Bigdeli
Journal:  Iran J Psychiatry       Date:  2017-01

5.  Environmental Enrichment Attenuates Morphine-Induced Conditioned Place Preference and Locomotor Sensitization in Maternally Separated Rat Pups.

Authors:  Soheyla Khalaji; Imanollah Bigdeli; Raheb Ghorbani; Hossein Miladi-Gorji
Journal:  Basic Clin Neurosci       Date:  2018-07-01

6.  Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice.

Authors:  Paul Mieske; Ute Hobbiesiefken; Carola Fischer-Tenhagen; Céline Heinl; Katharina Hohlbaum; Pia Kahnau; Jennifer Meier; Jenny Wilzopolski; Daniel Butzke; Juliane Rudeck; Lars Lewejohann; Kai Diederich
Journal:  Front Vet Sci       Date:  2022-08-18
  6 in total

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