| Literature DB >> 26274890 |
Wojciech J Dziechciejewski1, Regina Weber1, Oliver Sowada1, Mike M K Boysen1.
Abstract
Cycloalkenes with exocyclic acceptor substituents still remain challenging substrates for enantioselective rhodium-catalyzed 1,4-addition. Cycloalkene carbonitriles and carboxylates have been investigated, and a highly diastereo- and enantioselective protocol for 1,4-addition to cyclopentene and cycloheptene carbonitrile has been developed. This new asymmetric transformation was subsequently applied in the asymmetric formal synthesis of the drug candidate Vabicaserin.Entities:
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Year: 2015 PMID： 26274890 DOI： 10.1021/acs.orglett.5b01849
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005