Literature DB >> 26274753

Evaluating the British sarcoma referral form.

M A Smolle1, A Leithner1, R J Grimer2.   

Abstract

INTRODUCTION: This study investigated the accuracy of general practitioner (GP) referrals under the two-week wait pathway for soft tissue sarcomas and whether the current National Institute for Health and Care Excellence criteria should be refined.
METHODS: All patients referred under the two-week wait system to one centre over the course of one year were reviewed. Comparison was made between the criteria identified by the GP and those confirmed by the centre to assess the accuracy of the referrals, and to identify what criteria predicted malignancy.
RESULTS: Overall, 135 patients were referred to our unit with a mean age of 56.4 years. Of these, 45 (33%) were found to have a malignant tumour. Factors identified by the GP were accurate in 74% of cases. The best predictor of malignancy was 'size >5cm' (76% sensitivity) while 'pain' was the least useful (27% sensitivity). Lowering the threshold for concern to a size of >4cm increased sensitivity to 89%. Although 106 patients had undergone some form of imaging prior to referral, this did not increase the likelihood of malignancy being detected. The combination of factors most likely to predict malignancy was a size of >5cm, increase in size, deep location and no pain (10 out of 13 referrals, 77% accuracy).
CONCLUSIONS: Based on the results of this study, we recommend an adaption of the existing features for concern. The new feature for concern should be 'size >4cm' and the factor 'pain' should be removed from the urgent referral form.

Entities:  

Keywords:  Clinical features; Soft tissue sarcoma; Two-week wait

Mesh:

Year:  2015        PMID: 26274753      PMCID: PMC5126240          DOI: 10.1308/rcsann.2015.0002

Source DB:  PubMed          Journal:  Ann R Coll Surg Engl        ISSN: 0035-8843            Impact factor:   1.891


  11 in total

1.  Trends in presentation of bone and soft tissue sarcomas over 25 years: little evidence of earlier diagnosis.

Authors:  G M Smith; G D Johnson; R J Grimer; S Wilson
Journal:  Ann R Coll Surg Engl       Date:  2011-10       Impact factor: 1.891

2.  Earlier diagnosis of bone and soft-tissue tumours.

Authors:  R J Grimer; T W R Briggs
Journal:  J Bone Joint Surg Br       Date:  2010-11

3.  Does the two-week rule pathway improve the diagnosis of soft tissue sarcoma? A retrospective review of referral patterns and outcomes over five years in a regional sarcoma centre.

Authors:  Tim D Pencavel; Dirk C Strauss; Greg P Thomas; J Meirion Thomas; Andrew J Hayes
Journal:  Ann R Coll Surg Engl       Date:  2010-05-19       Impact factor: 1.891

4.  The value of C-reactive protein and comorbidity in predicting survival of patients with high grade soft tissue sarcoma.

Authors:  Tomoki Nakamura; Robert Grimer; Czar Gaston; Matthew Francis; Jackie Charman; Piers Graunt; Astumasa Uchida; Akihiro Sudo; Lee Jeys
Journal:  Eur J Cancer       Date:  2012-10-08       Impact factor: 9.162

Review 5.  Prognostic factors in soft tissue sarcoma.

Authors:  Katja Maretty-Nielsen
Journal:  Dan Med J       Date:  2014-11       Impact factor: 1.240

6.  Staging of soft-tissue sarcomas. Prognostic analysis of clinical and pathological features.

Authors:  M K Saddegh; J Lindholm; A Lundberg; U Nilsonne; A Kreicbergs
Journal:  J Bone Joint Surg Br       Date:  1992-07

7.  ''Two-week waits"-are they leading to earlier diagnosis of soft-tissue sarcomas?

Authors:  W St J Taylor; R J Grimer; S R Carter; R M Tillman; A Abudu; L Jeys
Journal:  Sarcoma       Date:  2010-09-26

Review 8.  Soft tissue sarcoma of the trunk and extremities.

Authors:  E Tukiainen; T Böhling; R Huuhtanen
Journal:  Scand J Surg       Date:  2003       Impact factor: 2.360

9.  Soft-tissue sarcomas of the upper extremity: surgical treatment and outcome.

Authors:  Pentscho Popov; Erkki Tukiainen; Sirpa Asko-Seljavaara; Riikka Huuhtanen; Martti Virolainen; Pekka Virkkunen; Carl Blomqvist
Journal:  Plast Reconstr Surg       Date:  2004-01       Impact factor: 4.730

10.  Early symptoms of bone and soft tissue sarcomas: could they be diagnosed earlier?

Authors:  A George; R Grimer
Journal:  Ann R Coll Surg Engl       Date:  2012-05       Impact factor: 1.891

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  4 in total

Review 1.  [Systematic planning of surgery for soft tissue sarcoma of the extremities].

Authors:  J Jakob; J Schmolders
Journal:  Chirurg       Date:  2019-06       Impact factor: 0.955

2.  Routes to Diagnosis for Suspected Sarcoma: The Impact of Symptoms and Clinical Findings on the Diagnostic Process.

Authors:  Heidi Buvarp Dyrop; Peter Vedsted; Mathias Rædkjær; Akmal Safwat; Johnny Keller
Journal:  Sarcoma       Date:  2016-12-26

3.  Diagnosis and treatment of soft-tissue sarcomas of the extremities and trunk.

Authors:  Maria Anna Smolle; Dimosthenis Andreou; Per-Ulf Tunn; Joanna Szkandera; Bernadette Liegl-Atzwanger; Andreas Leithner
Journal:  EFORT Open Rev       Date:  2017-10-17

4.  Imaging investigations before referral to a sarcoma center delay the final diagnosis of musculoskeletal sarcoma.

Authors:  Heidi Buvarp Dyrop; Peter Vedsted; Mathias Rædkjær; Akmal Safwat; Johnny Keller
Journal:  Acta Orthop       Date:  2017-01-12       Impact factor: 3.717

  4 in total

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