Literature DB >> 26274361

Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies.

Pau Rocas1, Mireia Hoyos-Nogués2,3, Josep Rocas4, José M Manero2,3, Javier Gil2,3, Fernando Albericio1,3,5,6,7, Carlos Mas-Moruno2,3.   

Abstract

A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RGD peptides; antibacterial properties; multifunctional nanomaterials; surface functionalization; titanium osseointegration

Mesh：

Substances：

Year:  2015        PMID： 26274361     DOI： 10.1002/adhm.201500245

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  5 in total

1.  Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane-Polyurea Hybrid Nanocarrier.

Authors:  Joaquín Bonelli; Enrique Ortega-Forte; Anna Rovira; Manel Bosch; Oriol Torres; Cristina Cuscó; Josep Rocas; José Ruiz; Vicente Marchán
Journal:  Biomacromolecules       Date:  2022-06-13       Impact factor: 6.978

Review 2.  Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration.

Authors:  Fanying Meng; Zhifeng Yin; Xiaoxiang Ren; Zhen Geng; Jiacan Su
Journal:  Pharmaceutics       Date:  2022-05-17       Impact factor: 6.525

3.  Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands.

Authors:  Roberta Fraioli; Penelope M Tsimbouri; Leanne E Fisher; Angela H Nobbs; Bo Su; Stefanie Neubauer; Florian Rechenmacher; Horst Kessler; Maria-Pau Ginebra; Matthew J Dalby; José M Manero; Carlos Mas-Moruno
Journal:  Sci Rep       Date:  2017-11-27       Impact factor: 4.379

4.  Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility.

Authors:  Noemi Molina; Ana González; Donato Monopoli; Belinda Mentado; José Becerra; Leonor Santos-Ruiz; Yolanda Vida; Ezequiel Perez-Inestrosa
Journal:  Polymers (Basel)       Date:  2020-04-01       Impact factor: 4.329

5.  Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug.

Authors:  Marta Pérez-Hernández; Cristina Cuscó; Cristina Benítez-García; Joaquin Bonelli; Marina Nuevo-Fonoll; Aroa Soriano; David Martínez-García; Alain Arias-Betancur; María García-Valverde; Miguel F Segura; Roberto Quesada; Josep Rocas; Vanessa Soto-Cerrato; Ricardo Pérez-Tomás
Journal:  Biomedicines       Date:  2021-05-04
  5 in total

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