Vincent Chin-Hung Chen1,2,3,4, Yin-To Liao1,2, Dah-Cherng Yeh5, Hsien-Chun Tseng2,6, Robert Stewart7, Charles Tzu-Chi Lee8. 1. Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan. 2. School of Medicine, Chung Shan Medical University, Taichung, Taiwan. 3. Chang Gung University, Taiwan. 4. Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Taiwan. 5. Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan. 6. Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan. 7. King's College London, Institute of Psychiatry, London, UK. 8. Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
Abstract
OBJECTIVE: To investigate the association between antidepressant prescription and breast cancer. METHODS: The National Health Research Institute in Taiwan provided a database of 1 000 000 random subjects for this study. We identified 14 737 new antidepressant female users who were more than 15 years old during 1999-2005 with at least 10 prescriptions and one year exposure to an antidepressant. These were matched 1:1 by age and residence to non-antidepressant users from the same database to compare the risk of breast cancer. RESULTS: In a model adjusted by age, residence, insurance amount, and depressive disorder, antidepressant prescription was not associated with breast cancer risk. This held true for both selective serotonin re-uptake inhibitors (SSRIs) and tricyclic antidepressants. CONCLUSIONS: There was no evidence for an association between antidepressant prescription and the risk of breast cancer.
OBJECTIVE: To investigate the association between antidepressant prescription and breast cancer. METHODS: The National Health Research Institute in Taiwan provided a database of 1 000 000 random subjects for this study. We identified 14 737 new antidepressant female users who were more than 15 years old during 1999-2005 with at least 10 prescriptions and one year exposure to an antidepressant. These were matched 1:1 by age and residence to non-antidepressant users from the same database to compare the risk of breast cancer. RESULTS: In a model adjusted by age, residence, insurance amount, and depressive disorder, antidepressant prescription was not associated with breast cancer risk. This held true for both selective serotonin re-uptake inhibitors (SSRIs) and tricyclic antidepressants. CONCLUSIONS: There was no evidence for an association between antidepressant prescription and the risk of breast cancer.
Authors: Antonio Asensi-Cantó; María Dolores López-Abellán; Verónica Castillo-Guardiola; Ana María Hurtado; Mónica Martínez-Penella; Ginés Luengo-Gil; Pablo Conesa-Zamora Journal: Cancers (Basel) Date: 2022-07-01 Impact factor: 6.575