| Literature DB >> 26273823 |
Gemma Hammerton, Liam Mahedy, Becky Mars, Gordon T Harold, Anita Thapar, Stanley Zammit, Stephan Collishaw.
Abstract
Entities:
Year: 2015 PMID: 26273823 PMCID: PMC4537257 DOI: 10.1371/journal.pone.0136367
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Logistic regression analyses showing association between each class of maternal depression symptoms in comparison to minimal class (reference group) and subsequent offspring past year suicidal ideation at age 16 years (Odds Ratios (OR) and 95% Confidence Intervals (95% CI) displayed).
| OR (95% CI) | ||||
|---|---|---|---|---|
| Maternal depression class | Model 1 (unadjusted) | Model 2 | Model 3 | Model 4 |
| Minimal ( | Reference group | |||
| Mild ( | 1.31 (1.09, 1.59) | 1.23 (1.01, 1.49) | 1.22 (1.01, 1.49) | 1.22 (1.00, 1.48) |
| Increasing ( | 1.59 (1.16, 2.19) | 1.47 (1.06, 2.04) | 1.43 (1.02, 1.99) | 1.37 (.97, 1.92) |
| Sub-threshold ( | 1.85 (1.50, 2.27) | 1.60 (1.29, 1.99) | 1.57 (1.26, 1.95) | 1.51 (1.21, 1.88) |
| Chronic-severe ( | 3.04 (2.19, 4.21) | 2.38 (1.68, 3.37) | 2.23 (1.57, 3.19) | 2.01 (1.40, 2.87) |
Imputed N = 10,559;
# p<.10;
*p ≤ 0.05;
** p ≤ 0.01;
*** p ≤ 0.001
a Adjusting for confounders assessed in pregnancy (housing tenure, marital status, maternal level of education, smoking in pregnancy, maternal family history of depression and maternal psychiatric disorder before pregnancy)
b Additionally adjusting for maternal suicide attempt (from pregnancy to child age 11 years)
c Additionally adjusting for DSM-IV diagnosis of MDD in offspring (assessed using the DAWBA at ages 7, 10, 13 and 15 years)
Logistic regression analyses showing association between each class of maternal depression symptoms in comparison to minimal class (reference group) and subsequent offspring past year suicidal ideation at age 16 years using alternative approaches to dealing with missing data (Odds Ratios (OR) and 95% Confidence Intervals (95% CI) displayed).
| OR (95% CI) | |||
|---|---|---|---|
| Maternal depression class | Model 1 (using full imputed data; | Model 2 (imputing those that were sent Q; | Model 3 (complete cases; |
| Minimal | Reference group | ||
| Mild | 1.22 (1.00, 1.48) | 1.22 (.98, 1.50) | 1.17 (.93, 1.47) |
| Increasing | 1.37 (.97, 1.92) | 1.38 (.96, 1.97) | 1.27 (.84, 1.90) |
| Sub-threshold | 1.51 (1.21, 1.88) | 1.50 (1.19, 1.90) | 1.58 (1.20, 2.09) |
| Chronic-severe | 2.01 (1.40, 2.87) | 2.08 (1.43, 3.02) | 2.03 (1.31, 3.15) |
# p<.10;
*p ≤ 0.05;
** p ≤ 0.01;
*** p ≤ 0.001
a All models adjusted for confounders assessed in pregnancy, maternal suicide attempt and DSM-IV diagnosis of MDD in offspring
b Model 1 shows the fully adjusted results using the full imputed dataset
c Model 2 shows the fully adjusted results using imputed data for those offspring that were sent the questionnaire at age 16 years
d Model 3 shows the fully adjusted results using only those with complete data on all variables in analysis