A Javed1, I J Kullo2, P Babu Balagopal3, S Kumar1. 1. Division of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA. 2. Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA. 3. Division of Biomedical Research, Nemours Children's Clinic, Jacksonville, FL, USA.
Abstract
BACKGROUND: Obesity in children is associated with vitamin D deficiency and endothelial dysfunction. It is not known if treatment with vitamin D improves endothelial function in obese adolescents. OBJECTIVE: This study aimed to determine whether treatment with vitamin D3 improves endothelial function in obese adolescents. METHODS: Nineteen obese adolescents, 13-18 years of age, with 25-hydroxy vitamin D (25[OH]D) levels <75 nmol L(-1) were treated with 100 000 IU vitamin D3 orally once a month for 3 months in an open-label, single-centre prospective trial. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at study entry and 1 month after the third dose of vitamin D3 . Biochemical parameters, including calcium, fasting lipids, glucose, insulin and high-sensitivity C-reactive protein, were also obtained. RESULTS: Mean 25(OH)D levels increased from 55.9 ± 12.2 to 86.9 ± 16.7 nmol L(-1) (P < 0.01). There was no correlation between 25(OH)D levels and brachial artery FMD. The brachial artery FMD (%) did not change significantly following vitamin D3 treatment (9.5 ± 3.53 vs. 10.3 ± 3.83, P = 0.83). Serum parathyroid hormone declined from 3.8 ± 1.5 to 3.1 ± 1 pmol L(-1) (P = 0.01). The remainder of biochemical measurements did not show a significant change. CONCLUSIONS: Treatment with vitamin D3 , 100 000 IU once a month for 3 months was effective in increasing 25(OH)D levels in obese adolescents but did not impact endothelial function.
BACKGROUND:Obesity in children is associated with vitamin Ddeficiency and endothelial dysfunction. It is not known if treatment with vitamin D improves endothelial function in obese adolescents. OBJECTIVE: This study aimed to determine whether treatment with vitamin D3 improves endothelial function in obese adolescents. METHODS: Nineteen obese adolescents, 13-18 years of age, with 25-hydroxy vitamin D (25[OH]D) levels <75 nmol L(-1) were treated with 100 000 IU vitamin D3 orally once a month for 3 months in an open-label, single-centre prospective trial. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at study entry and 1 month after the third dose of vitamin D3 . Biochemical parameters, including calcium, fasting lipids, glucose, insulin and high-sensitivity C-reactive protein, were also obtained. RESULTS: Mean 25(OH)D levels increased from 55.9 ± 12.2 to 86.9 ± 16.7 nmol L(-1) (P < 0.01). There was no correlation between 25(OH)D levels and brachial artery FMD. The brachial artery FMD (%) did not change significantly following vitamin D3 treatment (9.5 ± 3.53 vs. 10.3 ± 3.83, P = 0.83). Serum parathyroid hormone declined from 3.8 ± 1.5 to 3.1 ± 1 pmol L(-1) (P = 0.01). The remainder of biochemical measurements did not show a significant change. CONCLUSIONS: Treatment with vitamin D3 , 100 000 IU once a month for 3 months was effective in increasing 25(OH)D levels in obese adolescents but did not impact endothelial function.
Authors: Clifford J Rosen; Steven A Abrams; John F Aloia; Patsy M Brannon; Steven K Clinton; Ramon A Durazo-Arvizu; J Christopher Gallagher; Richard L Gallo; Glenville Jones; Christopher S Kovacs; JoAnn E Manson; Susan T Mayne; A Catharine Ross; Sue A Shapses; Christine L Taylor Journal: J Clin Endocrinol Metab Date: 2012-03-22 Impact factor: 5.958
Authors: Yanbin Dong; Inger S Stallmann-Jorgensen; Norman K Pollock; Ryan A Harris; Daniel Keeton; Ying Huang; Ke Li; Reda Bassali; De-huang Guo; Jeffrey Thomas; Gary L Pierce; Jennifer White; Michael F Holick; Haidong Zhu Journal: J Clin Endocrinol Metab Date: 2010-07-21 Impact factor: 5.958
Authors: Nancy G Sebring; Blakeley I Denkinger; Carolyn M Menzie; Lisa B Yanoff; Shamik J Parikh; Jack A Yanovski Journal: J Am Diet Assoc Date: 2007-05
Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638
Authors: Kumaravel Rajakumar; Charity G Moore; Arshad T Khalid; Abbe N Vallejo; Mohamed A Virji; Michael F Holick; Susan L Greenspan; Silva Arslanian; Steven E Reis Journal: Am J Clin Nutr Date: 2020-04-01 Impact factor: 7.045
Authors: Ana Cristina Pereira de Jesus Costa; Mércia Kelly Dos Santos Silva; Samae Batista de Oliveira; Luana Leite Silva; Alessandra Cruz Silva; Raidanes Barros Barroso; José de Ribamar Macedo Costa; Virlane Kelly Lima Hunaldo; Marcelino Santos Neto; Lívia Maia Pascoal; Márcia Caroline Nascimento Sá Ewerton Martins; Floriacy Stabnow Santos; Leonardo Hunaldo Dos Santos; Gledson Weslley Pereira Santos; Maria Aparecida Alves de Oliveira Serra; Ariadne Siqueira de Araújo Gordon; Thiago Moura de Araújo; Márcio Flávio Moura de Araújo Journal: J Nutr Metab Date: 2020-05-04
Authors: P S Gibson; A Quaglia; A Dhawan; H Wu; S Lanham-New; K H Hart; E Fitzpatrick; J B Moore Journal: Pediatr Obes Date: 2018-05-14 Impact factor: 4.000