Tae-Wook Kim1, Woo-Il Kim2, Je-Ho Mun1, Margaret Song1, Hoon-Soo Kim1, Byung-Soo Kim3, Moon-Bum Kim3, Hyun-Chang Ko4. 1. Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. 2. Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea. 3. Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Bio-Medical Research Institute, Pusan National University Hospital, Busan, Korea. 4. Department of Dermatology, Pusan National University School of Medicine, Yangsan, Korea. ; Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea. ; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Abstract
BACKGROUND: The oral mucosa is constantly exposed to several irritants and allergens including dental materials, but the role of contact allergy in oral disease is obscure. OBJECTIVE: To analyze positive patch test results in patients with oral diseases and evaluate the clinical relevance of oral diseases with contact allergy to dental materials. METHODS: We retrospectively analyzed patch test results with dental screening series in 44 patients with oral disease from 2004~2011. RESULTS: Oral diseases included oral lichen planus (54.5%), cheilitis (27.3%), burning mouth syndrome (9.1%), and others (9.1%). Thirty-one of 44 patients (70.5%) had positive reactions to one or more allergens. The most commonly detected allergens were gold sodium thiosulfate (25.0%) and nickel sulfate (25.0%), followed by potassium dichromate (22.7%), cobalt (15.9%), palladium (6.8%), mercury (4.5%), copper (4.5%), and methylhydroquinone (4.5%). Six of 24 patients with oral lichen planus had a symptom in areas adjacent to dental materials and positive patch test reactions to allergens contained in the suspected dental materials. CONCLUSION: Patch tests with dental screening series are worth considering for oral diseases, especially for oral lichen planus.
BACKGROUND: The oral mucosa is constantly exposed to several irritants and allergens including dental materials, but the role of contact allergy in oral disease is obscure. OBJECTIVE: To analyze positive patch test results in patients with oral diseases and evaluate the clinical relevance of oral diseases with contact allergy to dental materials. METHODS: We retrospectively analyzed patch test results with dental screening series in 44 patients with oral disease from 2004~2011. RESULTS:Oral diseases included oral lichen planus (54.5%), cheilitis (27.3%), burning mouth syndrome (9.1%), and others (9.1%). Thirty-one of 44 patients (70.5%) had positive reactions to one or more allergens. The most commonly detected allergens were gold sodium thiosulfate (25.0%) and nickel sulfate (25.0%), followed by potassium dichromate (22.7%), cobalt (15.9%), palladium (6.8%), mercury (4.5%), copper (4.5%), and methylhydroquinone (4.5%). Six of 24 patients with oral lichen planus had a symptom in areas adjacent to dental materials and positive patch test reactions to allergens contained in the suspected dental materials. CONCLUSION: Patch tests with dental screening series are worth considering for oral diseases, especially for oral lichen planus.
Authors: I M Van Hoogstraten; K E Andersen; B M Von Blomberg; D Boden; D P Bruynzeel; D Burrows; J G Camarasa; A Dooms-Goossens; G Kraal; A Lahti Journal: Clin Exp Immunol Date: 1991-09 Impact factor: 4.330