BACKGROUND: Chemoradiotherapy (CRT) is used to treat cervical lymph node(s) metastatic head and neck cancer patients. Evaluation and treatment of lymph node(s) after CRT is important to improve the prognosis. METHODS: Prior to CRT, we determined the TNM stage by visual and imaging examinations. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated from the results of fluorodeoxyglucose-positron emission tomography (FDG-PET). After CRT, the patients were divided in two groups-complete response (CR) and non-CR-and their responses were compared with the clinical characteristics. RESULTS: T4, N2b, N2c and TLG2.5 ≥ 18.8 were statistically significant predictive indices before CRT. The odds ratio, 95 % confidence interval and p value were, respectively-T4: 2.73, 1.15-6.51, 0.0230; N2b: 6.96, 1.50-32.3, 0.0132; N2c: 11.80, 2.37-58.50, 0.00258; and TLG2.5 ≥ 18.8: 6.25, 2.17-18.00, 0.000672. CONCLUSIONS: TLG was found to be a good predictive factor for metastatic lymph node(s) prior to CRT treatment. After CRT treatment, FDG-PET was found to be highly specific and useful for negative screening.
BACKGROUND: Chemoradiotherapy (CRT) is used to treat cervical lymph node(s) metastatic head and neck cancerpatients. Evaluation and treatment of lymph node(s) after CRT is important to improve the prognosis. METHODS: Prior to CRT, we determined the TNM stage by visual and imaging examinations. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated from the results of fluorodeoxyglucose-positron emission tomography (FDG-PET). After CRT, the patients were divided in two groups-complete response (CR) and non-CR-and their responses were compared with the clinical characteristics. RESULTS: T4, N2b, N2c and TLG2.5 ≥ 18.8 were statistically significant predictive indices before CRT. The odds ratio, 95 % confidence interval and p value were, respectively-T4: 2.73, 1.15-6.51, 0.0230; N2b: 6.96, 1.50-32.3, 0.0132; N2c: 11.80, 2.37-58.50, 0.00258; and TLG2.5 ≥ 18.8: 6.25, 2.17-18.00, 0.000672. CONCLUSIONS:TLG was found to be a good predictive factor for metastatic lymph node(s) prior to CRT treatment. After CRT treatment, FDG-PET was found to be highly specific and useful for negative screening.
Entities:
Keywords:
Chemoradiotherapy; Head and neck squamous cell carcinoma; Metastatic lymph node; Predictive factor; Total lesion glycolysis
Authors: Steven M. Larson; Yusuf Erdi; Timothy Akhurst; Madhu Mazumdar; Homer A. Macapinlac; Ronald D. Finn; Cecille Casilla; Melissa Fazzari; Neil Srivastava; Henry W.D. Yeung; John L. Humm; Jose Guillem; Robert Downey; Martin Karpeh; Alfred E. Cohen; Robert Ginsberg Journal: Clin Positron Imaging Date: 1999-05
Authors: George Fountzilas; Elisabeta Ciuleanu; Urania Dafni; George Plataniotis; Anna Kalogera-Fountzila; Epaminontas Samantas; Eleni Athanassiou; John Tzitzikas; Tudor Ciuleanu; Angelos Nikolaou; Panayiotis Pantelakos; Thomas Zaraboukas; Nikolaos Zamboglou; John Daniilidis; Nicolas Ghilezan Journal: Med Oncol Date: 2004 Impact factor: 3.064
Authors: Athanassios Argiris; Kerstin M Stenson; Bruce E Brockstein; Bharat B Mittal; Harold Pelzer; Merrill S Kies; Prathima Jayaram; Louis Portugal; Barry L Wenig; Fred R Rosen; Daniel J Haraf; Everett E Vokes Journal: Head Neck Date: 2004-05 Impact factor: 3.147
Authors: Dominic A X Schinagl; Paul N Span; Wim J Oyen; Johannes H A M Kaanders Journal: Eur J Nucl Med Mol Imaging Date: 2011-04-02 Impact factor: 9.236
Authors: H Katori; M Tsukuda; I Mochimatu; J Ishitoya; S Kawai; Y Mikami; H Matsuda; Y Tanigaki; C Horiuchi; Y Ikeda; T Taguchi; M Ono; T Yoshida; S Hirose; Y Sakuma; K Yamamoto Journal: Br J Cancer Date: 2004-01-26 Impact factor: 7.640
Authors: Aurélien Justet; Astrid Laurent-Bellue; Gabriel Thabut; Arnaud Dieudonné; Marie-Pierre Debray; Raphael Borie; Michel Aubier; Rachida Lebtahi; Bruno Crestani Journal: Respir Res Date: 2017-04-27