Yoo-Seok Yoon1, Ho-Seong Han2, Jai Young Cho1, YoungRok Choi1, Woohyung Lee1, Jae Yool Jang1, Hanlim Choi1. 1. Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Korea. 2. Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Korea. Electronic address: hanhs@snubh.org.
Abstract
BACKGROUND: Laparoscopic treatment for gallbladder cancer (GBC) has long been contraindicated, but few studies have demonstrated the oncologic outcomes of this treatment. The purpose of this study was to evaluate long-term survival after intended laparoscopic surgery for early-stage GBC based on our 10 years of experience. STUDY DESIGN: Between May 2004 and April 2014, eighty-three patients suspected of having early-stage GBC with no evidence of liver invasion were enrolled in the prospective protocol for laparoscopic surgery. Data for 45 of these patients with pathologically proven GBC were analyzed to determine the safety and oncologic outcomes of a laparoscopic approach to GBC. Twenty-six patients whose postoperative follow-up exceeded 5 years were investigated to determine the 5-year actual survival outcomes. RESULTS: Extended cholecystectomy, including laparoscopic lymphadenectomy, was performed in 32 patients and simple cholecystectomy in 13 patients. The T stages based on final pathologic results were Tis (n = 2), T1a (n = 10), T1b (n = 8), and T2 (n = 25). After a median follow-up of 60 months after surgery, recurrence was detected in 4 patients as distant metastases. There was no local recurrence around the gallbladder bed or lymphadenectomy. Disease-specific 5-year survival rate of the 45 patients was 94.2%. Disease-specific actual survival rate of 26 patients whose postoperative follow-up period exceeded 5 years was 92.3% at 5 years. CONCLUSIONS: The favorable long-term oncologic results shown in this study confirm the oncologic safety of laparoscopic cholecystectomy, including laparoscopic lymphadenectomy in selected patients with GBC.
BACKGROUND: Laparoscopic treatment for gallbladder cancer (GBC) has long been contraindicated, but few studies have demonstrated the oncologic outcomes of this treatment. The purpose of this study was to evaluate long-term survival after intended laparoscopic surgery for early-stage GBC based on our 10 years of experience. STUDY DESIGN: Between May 2004 and April 2014, eighty-three patients suspected of having early-stage GBC with no evidence of liver invasion were enrolled in the prospective protocol for laparoscopic surgery. Data for 45 of these patients with pathologically proven GBC were analyzed to determine the safety and oncologic outcomes of a laparoscopic approach to GBC. Twenty-six patients whose postoperative follow-up exceeded 5 years were investigated to determine the 5-year actual survival outcomes. RESULTS: Extended cholecystectomy, including laparoscopic lymphadenectomy, was performed in 32 patients and simple cholecystectomy in 13 patients. The T stages based on final pathologic results were Tis (n = 2), T1a (n = 10), T1b (n = 8), and T2 (n = 25). After a median follow-up of 60 months after surgery, recurrence was detected in 4 patients as distant metastases. There was no local recurrence around the gallbladder bed or lymphadenectomy. Disease-specific 5-year survival rate of the 45 patients was 94.2%. Disease-specific actual survival rate of 26 patients whose postoperative follow-up period exceeded 5 years was 92.3% at 5 years. CONCLUSIONS: The favorable long-term oncologic results shown in this study confirm the oncologic safety of laparoscopic cholecystectomy, including laparoscopic lymphadenectomy in selected patients with GBC.
Authors: Mia S DeSimone; Michael Goodman; Burcin Pehlivanoglu; Bahar Memis; Serdar Balci; Juan Carlos Roa; Kee-Taek Jang; Jin-Young Jang; Seung-Mo Hong; Kyoungbun Lee; Haeryoung Kim; Hye-Jeong Choi; Takashi Muraki; Juan Carlos Araya; Enrique Bellolio; Juan M Sarmiento; Shishir K Maithel; Hector F Losada; Olca Basturk; Michelle D Reid; Jill Koshiol; Volkan Adsay Journal: Virchows Arch Date: 2021-01-07 Impact factor: 4.064
Authors: Ji Hoon Park; Young Hoon Kim; Haeryoung Kim; Yoo-Seok Yoon; Young Rok Choi; Jai Young Cho; Yoon Jin Lee; Ho-Seong Han Journal: Surg Endosc Date: 2015-12-29 Impact factor: 4.584