Aline Rodrigues Pinto1,2, Nathani Cristina da Silva2, Luciana Pinato3. 1. Irmandade da Santa Casa de Misericórdia da cidade de Marília, Marilia, SP, Brazil. 2. Department of Speech-Language and Hearing Therapy, São Paulo State University, Av. Vicente Ferreira, 1278, Marília, SP, Brazil, CEP: 17515-901. 3. Department of Speech-Language and Hearing Therapy, São Paulo State University, Av. Vicente Ferreira, 1278, Marília, SP, Brazil, CEP: 17515-901. lpinato@marilia.unesp.br.
Abstract
PURPOSE: Inflammation and oxidative stress are involved in the process of chronic renal failure (CRF). CRF patients show indication of sleep disturbances, and the melatonin rhythm, which modulates sleep, is abnormal in these patients; however, it is still unclear whether inflammation could be related to the blockage of melatonin production and sleep disturbances in this population. The aim of this study was to characterize and correlate sleep, the melatonin rhythm, and the levels of the inflammatory cytokines tumor necrosis factor (TNF) and interleukin (IL)-6 in patients with CRF and controls. METHODS: Sleep was evaluated by the "Sleep Quality Index Pittsburgh" (PSQI) questionnaire, and melatonin and cytokine contents in saliva and blood samples, respectively, were analyzed by ELISA. RESULTS: The CRF group scored higher on the global PSQI, which indicates a lower sleep quality and a higher prevalence of sleep disorders, than the control group. The CRF individuals also showed lower melatonin content than the control groups, both during the day and at night, and lacked rhythmicity in melatonin production. The CRF group also showed higher contents of TNF and IL-6 than the control group and a negative correlation between TNF and melatonin content. CONCLUSION: These results suggest that the sleep disorders observed in the CRF group were probably related to the low production of melatonin observed in this population. The high level of TNF, as previously demonstrated in other pathologies, is probably involved in this blockage of melatonin production in CRF.
PURPOSE:Inflammation and oxidative stress are involved in the process of chronic renal failure (CRF). CRF patients show indication of sleep disturbances, and the melatonin rhythm, which modulates sleep, is abnormal in these patients; however, it is still unclear whether inflammation could be related to the blockage of melatonin production and sleep disturbances in this population. The aim of this study was to characterize and correlate sleep, the melatonin rhythm, and the levels of the inflammatory cytokines tumor necrosis factor (TNF) and interleukin (IL)-6 in patients with CRF and controls. METHODS: Sleep was evaluated by the "Sleep Quality Index Pittsburgh" (PSQI) questionnaire, and melatonin and cytokine contents in saliva and blood samples, respectively, were analyzed by ELISA. RESULTS: The CRF group scored higher on the global PSQI, which indicates a lower sleep quality and a higher prevalence of sleep disorders, than the control group. The CRF individuals also showed lower melatonin content than the control groups, both during the day and at night, and lacked rhythmicity in melatonin production. The CRF group also showed higher contents of TNF and IL-6 than the control group and a negative correlation between TNF and melatonin content. CONCLUSION: These results suggest that the sleep disorders observed in the CRF group were probably related to the low production of melatonin observed in this population. The high level of TNF, as previously demonstrated in other pathologies, is probably involved in this blockage of melatonin production in CRF.
Authors: Marije Russcher; Birgit Koch; Elsbeth Nagtegaal; Karien van der Putten; Piet ter Wee; Carlo Gaillard Journal: Front Biosci (Landmark Ed) Date: 2012-06-01
Authors: Antonio Carrillo-Vico; Patricia J Lardone; Nuria Alvarez-Sánchez; Ana Rodríguez-Rodríguez; Juan M Guerrero Journal: Int J Mol Sci Date: 2013-04-22 Impact factor: 5.923
Authors: Luciana Pinato; Sanseray da Silveira Cruz-Machado; Daiane G Franco; Leila M G Campos; Erika Cecon; Pedro A C M Fernandes; Jackson C Bittencourt; Regina P Markus Journal: Brain Struct Funct Date: 2013-12-22 Impact factor: 3.270