| Literature DB >> 26270567 |
James C Anderson1, Joshua P Barham1, Christopher D Rundell1.
Abstract
Reductive cyclization of 2-iminonitrostyrenes (from the condensation of 2-aminostyrenes with an aldehyde and subsequent nitration of the alkene) using a bifunctional thiourea catalyst and tert-butyl-Hantzsch ester leads to an intramolecular conjugate hydride addition nitro-Mannich reaction to give the corresponding cis-2-aryl-3-nitrotetrahydroquinolines as single diastereoisomers in high yields and enantioselectivities.Entities:
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Year: 2015 PMID： 26270567 DOI： 10.1021/acs.orglett.5b02036
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005