Annelienke M van Hulst1, Wouter Kroon1, Evi S van der Linden1, Lily Nagtzaam1, Sarah R Ottenhof1, Inge Wegner1,2, Amy C Gunning3,4, Wilko Grolman1,2, Weibel Braunius1,5. 1. Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands. 2. Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. 3. Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands. 4. Julius Center for Health Sciences and Primary Care, Utrecht, Utrecht, The Netherlands. 5. Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Abstract
BACKGROUND: The purpose of this systematic review was to determine the significance of the grade of dysplasia in the development of invasive carcinoma. METHODS: A systematic search was performed to identify all relevant evidence. Titles and abstracts were screened using predefined criteria. Remaining articles were critically appraised. Absolute risks and 95% confidence intervals (CIs) were calculated. RESULTS: Seven articles were included. Four studies demonstrated an increased risk for the development of laryngeal carcinoma from mild, moderate, and severe dysplasia. Three studies showed an increased risk between the categories of mild and moderate dysplasia. CONCLUSION: The risk of malignant transformation seems to increase with the grade of dysplasia, although percentages between studies are highly dissimilar. The wide variety and overlapping 95% CIs make it difficult to formulate a strong recommendation. However, moderate dysplasia is more prone for malignant transformation than previously thought, which might influence follow-up and treatment decisions in the future.
BACKGROUND: The purpose of this systematic review was to determine the significance of the grade of dysplasia in the development of invasive carcinoma. METHODS: A systematic search was performed to identify all relevant evidence. Titles and abstracts were screened using predefined criteria. Remaining articles were critically appraised. Absolute risks and 95% confidence intervals (CIs) were calculated. RESULTS: Seven articles were included. Four studies demonstrated an increased risk for the development of laryngeal carcinoma from mild, moderate, and severe dysplasia. Three studies showed an increased risk between the categories of mild and moderate dysplasia. CONCLUSION: The risk of malignant transformation seems to increase with the grade of dysplasia, although percentages between studies are highly dissimilar. The wide variety and overlapping 95% CIs make it difficult to formulate a strong recommendation. However, moderate dysplasia is more prone for malignant transformation than previously thought, which might influence follow-up and treatment decisions in the future.
Authors: Hans Edmund Eckel; Ricard Simo; Miquel Quer; Edward Odell; Vinidh Paleri; Jens Peter Klussmann; Marc Remacle; Elisabeth Sjögren; Cesare Piazza Journal: Eur Arch Otorhinolaryngol Date: 2020-10-14 Impact factor: 2.503
Authors: Edward Odell; Hans Edmund Eckel; Ricard Simo; Miquel Quer; Vinidh Paleri; Jens Peter Klussmann; Marc Remacle; Elisabeth Sjögren; Cesare Piazza Journal: Eur Arch Otorhinolaryngol Date: 2020-10-13 Impact factor: 2.503