PURPOSE: To compare lamina cribrosa (LC) and choroidal thicknesses using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with Parkinson's disease (PD) and healthy controls. METHODS: A total number of 44 eyes of 22 patients with PD and 50 eyes of 25 healthy subjects were utilized in this institutional cross-sectional study. After a complete ophthalmic examination, all eyes were imaged with OCT (RTVue-100 version 5.1 Fourier-domain optical coherence tomography; Optovue Inc., Fremont, CA, USA); LC and choroidal thickness were assessed. RESULTS: The mean LC thicknesses were 209.4 ± 40.2 μm in patients with PD and 292.5 ± 33.7 μm in control subjects. There was a significant difference in the mean LC thickness between the groups (p < 0.0001). The choroidal thickness measurements of the PD group at the subfoveal region and 1.5 mm temporal and 1.5 mm nasal to the fovea were 228.1 ± 44.3, 193.2 ± 41.4 and 188.4 ± 49.0 μm, respectively, whereas measurements for the controls were, respectively, 246.5 ± 38.2, 227.3 ± 34.7 and 216.7 ± 51.4 μm. The choroid was significantly thinner in eyes of the PD group compared to that of the controls (p = 0.001, p < 0.001, and p = 0.006). There was no significant correlation between the disease severity and OCT parameters. The duration of the disease showed a statistically significant negative correlation with LC (rs[94] = -0.700, p < 0.001), and average subfoveal and temporal and nasal choroid thicknesses (rs[94] = -0.282, p = 0.006; rs[94] = -0.324, p = 0.001, rs[94] = -0.240, and p = 0.020, respectively). CONCLUSIONS: Regardless of the disease severity, PD may cause atrophy and volume loss in the lamina cribrosa, and choroid. An enhanced depth imaging technique may be used as an additional modality in the diagnosis and follow-up of patients with PD.
PURPOSE: To compare lamina cribrosa (LC) and choroidal thicknesses using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with Parkinson's disease (PD) and healthy controls. METHODS: A total number of 44 eyes of 22 patients with PD and 50 eyes of 25 healthy subjects were utilized in this institutional cross-sectional study. After a complete ophthalmic examination, all eyes were imaged with OCT (RTVue-100 version 5.1 Fourier-domain optical coherence tomography; Optovue Inc., Fremont, CA, USA); LC and choroidal thickness were assessed. RESULTS: The mean LC thicknesses were 209.4 ± 40.2 μm in patients with PD and 292.5 ± 33.7 μm in control subjects. There was a significant difference in the mean LC thickness between the groups (p < 0.0001). The choroidal thickness measurements of the PD group at the subfoveal region and 1.5 mm temporal and 1.5 mm nasal to the fovea were 228.1 ± 44.3, 193.2 ± 41.4 and 188.4 ± 49.0 μm, respectively, whereas measurements for the controls were, respectively, 246.5 ± 38.2, 227.3 ± 34.7 and 216.7 ± 51.4 μm. The choroid was significantly thinner in eyes of the PD group compared to that of the controls (p = 0.001, p < 0.001, and p = 0.006). There was no significant correlation between the disease severity and OCT parameters. The duration of the disease showed a statistically significant negative correlation with LC (rs[94] = -0.700, p < 0.001), and average subfoveal and temporal and nasal choroid thicknesses (rs[94] = -0.282, p = 0.006; rs[94] = -0.324, p = 0.001, rs[94] = -0.240, and p = 0.020, respectively). CONCLUSIONS: Regardless of the disease severity, PD may cause atrophy and volume loss in the lamina cribrosa, and choroid. An enhanced depth imaging technique may be used as an additional modality in the diagnosis and follow-up of patients with PD.
Authors: Joana M Afonso; Manuel Falcão; Frank Schlichtenbrede; Fernando Falcão-Reis; Sérgio Estrela Silva; Till M Schneider Journal: Front Neurol Date: 2017-05-01 Impact factor: 4.003
Authors: Elena Garcia-Martin; Luis E Pablo; Maria P Bambo; Raquel Alarcia; Vicente Polo; Jose M Larrosa; Elisa Vilades; Beatriz Cameo; Elvira Orduna; Teresa Ramirez; Maria Satue Journal: PLoS One Date: 2017-05-16 Impact factor: 3.240
Authors: Alicia López-de-Eguileta; Carmen Lage; Sara López-García; Ana Pozueta; María García-Martínez; Martha Kazimierczak; María Bravo; María de Arcocha-Torres; Ignacio Banzo; Julio Jimenez-Bonilla; Andrea Cerveró; Eloy Rodríguez-Rodríguez; Pascual Sánchez-Juan; Alfonso Casado Journal: Alzheimers Dement (N Y) Date: 2019-10-09
Authors: Gregory L Brown; Mona L Camacci; Sean D Kim; Stephanie Grillo; James V Nguyen; Douglas A Brown; Sarah P Ullah; Mechelle M Lewis; Guangwei Du; Lan Kong; Jeffrey M Sundstrom; Xuemei Huang; Esther M Bowie Journal: J Parkinsons Dis Date: 2021 Impact factor: 5.568