Literature DB >> 26266214

Influence of Vitamin D & Calcium Supplementation in the Management of Periodontitis.

Jayachandran Perayil1, Keerthy S Menon2, Seema Kurup3, Anju Elizebath Thomas4, Angel Fenol5, Rajesh Vyloppillil5, Anuradha Bhaskar6, Sai Megha7.   

Abstract

INTRODUCTION: It has long been recognized that vitamin D is a hormone and were many studies reporting that patients in periodontal maintenance programs taking vitamin D and calcium supplementation had a trend for better periodontal health compared to patients not taking supplementation. AIM: To evaluate the effect of vitamin D and calcium supplementation in reducing gingival inflammation, using clinical parameters like gingival index (GI), oral hygiene index-simplified (OHIS), probing pocket depth (PPD), clinical attachment level (CAL) and bone density (BD). Also, to assess whether calcium and vitamin D oral supplementation influences alveolar Bone Density (BD). DESIGN AND SETTINGS: A nonrandomised clinical trial done in Amrita School of dentistry, Kochi, India.
MATERIALS AND METHODS: Group A taking vitamin D (250IU/day) and calcium (500 mg/day) supplementation, and Group B were not taking oral supplementation. All subjects had at least one or more teeth with chronic moderate periodontitis. Digital Orthopantomogram images were taken to assess bone density. Data were collected at baseline and three months. STATISTICAL ANALYSIS USED: OHI-S, GI, PPD, CAL, and Bone Densities (BD) were calculated per group. Karl Pearson Coefficient of correlation was used to test correlation of bone density with GI and OHI -S. Intergroup comparison of parameters were done using Independent two Sample t-test. Intragroup comparison of parameters at recall interval was done using Paired sample t-test. The results were considered statistically significant when p-value was <0.05.
RESULTS: Both Groups showed significant change in the periodontal parameters and bone density after three months and intragroup comparison showed highly significant results for vitamin D group in relation to GI, OHI S and bone density.
CONCLUSION: Calcium and vitamin D supplementation has got a positive effect on periodontal health and it can be used as an adjunct to non surgical periodontal therapy.

Entities:  

Keywords:  Calcium carbonate; Cholecalciferol; Recolonization

Year:  2015        PMID: 26266214      PMCID: PMC4525604          DOI: 10.7860/JCDR/2015/12292.6091

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  32 in total

1.  Presence of 25(OH) D deficiency in a rural North Indian village despite abundant sunshine.

Authors:  R Goswami; N Kochupillai; Nandita Gupta; Deepti Goswami; Namrata Singh; Anuradha Dudha
Journal:  J Assoc Physicians India       Date:  2008-10

2.  Vitamin-D deficiency in Asians at home and in Britain.

Authors:  P Hodgkin; P M Hine; G H Kay; G A Lumb; S W Stanbury
Journal:  Lancet       Date:  1973-07       Impact factor: 79.321

3.  The Gingival Index, the Plaque Index and the Retention Index Systems.

Authors:  H Löe
Journal:  J Periodontol       Date:  1967 Nov-Dec       Impact factor: 6.993

4.  Recolonization of the subgingival microflora after scaling and root planing in human periodontitis.

Authors:  L Sbordone; L Ramaglia; E Gulletta; V Iacono
Journal:  J Periodontol       Date:  1990-09       Impact factor: 6.993

5.  Vitamin D-mediated induction of innate immunity in gingival epithelial cells.

Authors:  Laura McMahon; Kyell Schwartz; Ozlem Yilmaz; Eleith Brown; Lisa K Ryan; Gill Diamond
Journal:  Infect Immun       Date:  2011-03-21       Impact factor: 3.441

6.  The impact of vitamin D status on periodontal surgery outcomes.

Authors:  J D Bashutski; R M Eber; J S Kinney; E Benavides; S Maitra; T M Braun; W V Giannobile; L K McCauley
Journal:  J Dent Res       Date:  2011-05-09       Impact factor: 6.116

7.  Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.

Authors:  Larisa Nonn; Lihong Peng; David Feldman; Donna M Peehl
Journal:  Cancer Res       Date:  2006-04-15       Impact factor: 12.701

8.  Effect of vitamin D supplementation on bone health parameters of healthy young Indian women.

Authors:  Nidhi Malhotra; Ambrish Mithal; Sushil Gupta; Manoj Shukla; Madan Godbole
Journal:  Arch Osteoporos       Date:  2009-07-14       Impact factor: 2.617

9.  Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model.

Authors:  Paul H Anderson; Rebecca K Sawyer; Alison J Moore; Brian K May; Peter D O'Loughlin; Howard A Morris
Journal:  J Bone Miner Res       Date:  2008-11       Impact factor: 6.741

10.  Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production.

Authors:  A K Bhalla; E P Amento; S M Krane
Journal:  Cell Immunol       Date:  1986-04-01       Impact factor: 4.868

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  7 in total

1.  Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis.

Authors:  Vanessa Machado; Sofia Lobo; Luís Proença; José João Mendes; João Botelho
Journal:  Nutrients       Date:  2020-07-22       Impact factor: 5.717

2.  Calcium and vitamin D supplementation and/or periodontal therapy in the treatment of periodontitis among Brazilian pregnant women: protocol of a feasibility randomised controlled trial (the IMPROVE trial).

Authors:  Paula Guedes Cocate; Gilberto Kac; Berit L Heitmann; Paulo Nadanovsky; Maria Cláudia da Veiga Soares Carvalho; Camila Benaim; Michael Maia Schlüssel; Maria Beatriz Trindade de Castro; Nadya Helena Alves-Santos; Amanda Farnum Baptista; Michael F Holick; Rana R Mokhtar; Alessandra Raymundo Bomfim; Amanda Rodrigues Amorim Adegboye
Journal:  Pilot Feasibility Stud       Date:  2019-03-05

3.  Dairy Food Consumption is Inversely Associated with the Prevalence of Periodontal Disease in Korean Adults.

Authors:  Kyueun Lee; Jihye Kim
Journal:  Nutrients       Date:  2019-05-09       Impact factor: 5.717

4.  Effect of Supplementation of Vitamin D in Patients with Periodontitis Evaluated before and after Nonsurgical Therapy.

Authors:  Shree Mohan Mishra; P L Ravishankar; V Pramod; Prem Blaisie Rajula; K Gayathri; Mohammad Khursheed Alam; A Thirumal Raj; Shilpa Bhandi; Shankargouda Patil
Journal:  Biomed Res Int       Date:  2022-08-08       Impact factor: 3.246

Review 5.  Calcium and Vitamin D Supplementation as Non-Surgical Treatment for Periodontal Disease with a Focus on Female Patients: Literature Review.

Authors:  Zana Sllamniku Dalipi; Fatmir Dragidella
Journal:  Dent J (Basel)       Date:  2022-07-01

6.  Severe, Treatment-Refractory Periodontitis and Vitamin D Deficiency: A Multidisciplinary Case Report.

Authors:  Figliuzzi Michele Mario; Parentela Luca; Aiello Domenico; Altilia Simone
Journal:  Case Rep Dent       Date:  2022-10-11

7.  Could Vitamin D3 Deficiency Influence Malocclusion Development?

Authors:  Anna Leszczyszyn; Sylwia Hnitecka; Marzena Dominiak
Journal:  Nutrients       Date:  2021-06-21       Impact factor: 5.717

  7 in total

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