Literature DB >> 26265425

Highly Branched Poly(β-Amino Esters): Synthesis and Application in Gene Delivery.

Lara Cutlar1, Dezhong Zhou1, Yongsheng Gao1, Tianyu Zhao1, Udo Greiser1, Wei Wang1,2, Wenxin Wang1,2.   

Abstract

Highly branched poly(β-amino esters) (HPAEs) are developed via a facile and controllable "A2+B3/B2" strategy successfully. As nonviral gene delivery vectors, the performance of HPAEs is superior to the well-studied linear counterpart as well as the leading commercial reagent Superfect. When combined with minicircle DNA construct, HPAEs can achieve ultrahigh gene transfection efficiency, especially in keratinocytes.

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Year:  2015        PMID： 26265425     DOI： 10.1021/acs.biomac.5b00966

Source DB:  PubMed          Journal:  Biomacromolecules        ISSN： 1525-7797            Impact factor:   6.988


  10 in total

Review 1.  Non-viral nucleic acid containing nanoparticles as cancer therapeutics.

Authors:  Kristen L Kozielski; Yuan Rui; Jordan J Green
Journal:  Expert Opin Drug Deliv       Date:  2016-06-06       Impact factor: 6.648

Review 2.  Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities.

Authors:  Johan Karlsson; Kelly R Rhodes; Jordan J Green; Stephany Y Tzeng
Journal:  Expert Opin Drug Deliv       Date:  2020-07-31       Impact factor: 6.648

3.  Differentially Branched Ester Amine Quadpolymers with Amphiphilic and pH-Sensitive Properties for Efficient Plasmid DNA Delivery.

Authors:  David R Wilson; Yuan Rui; Kamran Siddiq; Denis Routkevitch; Jordan J Green
Journal:  Mol Pharm       Date:  2019-01-18       Impact factor: 4.939

4.  Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing.

Authors:  Yuan Rui; David R Wilson; Katie Sanders; Jordan J Green
Journal:  ACS Appl Mater Interfaces       Date:  2019-03-08       Impact factor: 9.229

5.  Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs.

Authors:  James C Kaczmarek; Asha K Patel; Kevin J Kauffman; Owen S Fenton; Matthew J Webber; Michael W Heartlein; Frank DeRosa; Daniel G Anderson
Journal:  Angew Chem Int Ed Engl       Date:  2016-09-30       Impact factor: 15.336

6.  Highly branched  poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells.

Authors:  Shuai Liu; Yongsheng Gao; Dezhong Zhou; Ming Zeng; Fatma Alshehri; Ben Newland; Jing Lyu; Jonathan O'Keeffe-Ahern; Udo Greiser; Tianying Guo; Fengzhi Zhang; Wenxin Wang
Journal:  Nat Commun       Date:  2019-07-24       Impact factor: 14.919

7.  Development of Minicircle Vectors Encoding COL7A1 Gene with Human Promoters for Non-Viral Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa.

Authors:  Xianqing Wang; Fatma Alshehri; Darío Manzanares; Yinghao Li; Zhonglei He; Bei Qiu; Ming Zeng; Sigen A; Irene Lara-Sáez; Wenxin Wang
Journal:  Int J Mol Sci       Date:  2021-11-26       Impact factor: 5.923

8.  Non-viral delivery of CRISPR-Cas9 complexes for targeted gene editing via a polymer delivery system.

Authors:  Jonathan O'Keeffe Ahern; Irene Lara-Sáez; Dezhong Zhou; Rodolfo Murillas; Jose Bonafont; Ángeles Mencía; Marta García; Darío Manzanares; Jennifer Lynch; Ruth Foley; Qian Xu; A Sigen; Fernando Larcher; Wenxin Wang
Journal:  Gene Ther       Date:  2021-08-06       Impact factor: 4.184

9.  The transition from linear to highly branched poly(β-amino ester)s: Branching matters for gene delivery.

Authors:  Dezhong Zhou; Lara Cutlar; Yongsheng Gao; Wei Wang; Jonathan O'Keeffe-Ahern; Sean McMahon; Blanca Duarte; Fernando Larcher; Brian J Rodriguez; Udo Greiser; Wenxin Wang
Journal:  Sci Adv       Date:  2016-06-17       Impact factor: 14.136

10.  A pH- and Bioreducible Cationic Copolymer with Amino Acids and Piperazines for Adenovirus Delivery.

Authors:  Thavasyappan Thambi; Jeongmin Lee; A-Rum Yoon; Dayananda Kasala; Chae-Ok Yun
Journal:  Pharmaceutics       Date:  2022-03-09       Impact factor: 6.321
  10 in total

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