| Literature DB >> 26265385 |
Abstract
We can now control hepatitis B virus infection by continuously administering nucleoside and nucleotide analogues such as entecavir and tenofovir. These drugs are generally safe and sufficiently effective, but future drugs are needed that can show off-treatment efficacy--in other words, eradication of latent hepatitis B virus DNA (covalently closed circular DNA) in the hepatocytes. This article is an overview of new drugs under development and some novel strategies to inhibit hepatitis B virus proliferation.Entities:
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Year: 2015 PMID: 26265385 DOI: 10.1007/s12328-015-0590-y
Source DB: PubMed Journal: Clin J Gastroenterol ISSN: 1865-7265