Literature DB >> 26265385

Future therapy for hepatitis B virus infection.

Masahito Minami1.   

Abstract

We can now control hepatitis B virus infection by continuously administering nucleoside and nucleotide analogues such as entecavir and tenofovir. These drugs are generally safe and sufficiently effective, but future drugs are needed that can show off-treatment efficacy--in other words, eradication of latent hepatitis B virus DNA (covalently closed circular DNA) in the hepatocytes. This article is an overview of new drugs under development and some novel strategies to inhibit hepatitis B virus proliferation.

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Year:  2015        PMID: 26265385     DOI: 10.1007/s12328-015-0590-y

Source DB:  PubMed          Journal:  Clin J Gastroenterol        ISSN: 1865-7265


  30 in total

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Authors: 
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5.  Durability of HBeAg seroconversion following antiviral therapy for chronic hepatitis B: relation to type of therapy and pretreatment serum hepatitis B virus DNA and alanine aminotransferase.

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Review 6.  Harnessing the biology of IL-7 for therapeutic application.

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7.  A 3-year clinical trial of lamivudine in treatment of patients with chronic hepatitis B.

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Journal:  Hepatobiliary Pancreat Dis Int       Date:  2004-05

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Journal:  Hepatology       Date:  2009-05       Impact factor: 17.425

9.  Long-term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA.

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Review 10.  NTCP and beyond: opening the door to unveil hepatitis B virus entry.

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  1 in total

Review 1.  Research progress of therapeutic vaccines for treating chronic hepatitis B.

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Journal:  Hum Vaccin Immunother       Date:  2017-01-24       Impact factor: 3.452

  1 in total

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