Melinda Magyari1, Nils Koch-Henriksen2, Claudia C Pfleger3, Per Soelberg Sørensen4. 1. Danish Multiple Sclerosis Center, Department of Neurology, and the Danish Multiple Sclerosis Registry, Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark. Electronic address: melinda_magyari@dadlnet.dk. 2. Clinical Institute, Department of Clinical Epidemiology, University of Aarhus, Denmark; Danish Multiple Sclerosis Registry, Rigshospitalet, and University of Copenhagen, Denmark. 3. Department of Neurology, Aalborg University Hospital, Aalborg, Denmark. 4. Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Abstract
BACKGROUND: The incidence of multiple sclerosis (MS) in Denmark has doubled in women since 1970, whereas it has been almost unchanged in men. The rapid epidemiological changes suggest that environmental factors may modify the risk of MS. OBJECTIVES: To investigate whether occupational, physical, or social environmental influence the risk of MS differently in women than in men. METHODS: The cohort consists of all 1403 patients (939 women, 464 men) identified through Danish Multiple Sclerosis Registry aged 1-55 of years at clinical onset between 2000 and 2004, and up to 25 control persons for each case, matched by sex, year of birth and residential municipality. The same cohort was previously used to investigate the influence of the reproductive factors on the risk of MS. RESULTS: By linkage to Danish population registers we found a slight albeit statistically significant excess for 6 female MS patients who had been employed in agriculture: OR 3.52; 95% CI 1.38-9.00, p=0.008 (0.046 when corrected for multiple significance) and a trend for exposure to outdoor work in 12 : OR 1.94, 95% CI 1.06-3.55, p=0.03 (0.09 when corrected for multiple significance), but the numbers of cases were small, and the effects were not found in men. Educational level, housing conditions in youth, or the presence of children unrelated by blood in the household did not influence the risk of MS. CONCLUSIONS: Our study did not reveal any additional factors beyond the previously published childbirths which could explain the extent of the MS incidence increase in women.
BACKGROUND: The incidence of multiple sclerosis (MS) in Denmark has doubled in women since 1970, whereas it has been almost unchanged in men. The rapid epidemiological changes suggest that environmental factors may modify the risk of MS. OBJECTIVES: To investigate whether occupational, physical, or social environmental influence the risk of MS differently in women than in men. METHODS: The cohort consists of all 1403 patients (939 women, 464 men) identified through Danish Multiple Sclerosis Registry aged 1-55 of years at clinical onset between 2000 and 2004, and up to 25 control persons for each case, matched by sex, year of birth and residential municipality. The same cohort was previously used to investigate the influence of the reproductive factors on the risk of MS. RESULTS: By linkage to Danish population registers we found a slight albeit statistically significant excess for 6 female MS patients who had been employed in agriculture: OR 3.52; 95% CI 1.38-9.00, p=0.008 (0.046 when corrected for multiple significance) and a trend for exposure to outdoor work in 12 : OR 1.94, 95% CI 1.06-3.55, p=0.03 (0.09 when corrected for multiple significance), but the numbers of cases were small, and the effects were not found in men. Educational level, housing conditions in youth, or the presence of children unrelated by blood in the household did not influence the risk of MS. CONCLUSIONS: Our study did not reveal any additional factors beyond the previously published childbirths which could explain the extent of the MS incidence increase in women.
Authors: Anna Knyszyńska; Karolina Skonieczna-Żydecka; Dorota Koziarska; Laura Stachowska; Artur Kotwas; Monika Kulaszyńska; Anna Lubkowska; Beata Karakiewicz Journal: Int J Environ Res Public Health Date: 2022-05-27 Impact factor: 4.614
Authors: Juan-Manuel Anaya; Carolina Ramirez-Santana; Maria A Alzate; Nicolas Molano-Gonzalez; Adriana Rojas-Villarraga Journal: Front Immunol Date: 2016-04-26 Impact factor: 7.561