Michel Bouchoucha1,2, Marinos Fysekidis3, Chantal Julia4, Gheorghe Airinei5, Jean-Marc Catheline6, Régis Cohen3, Robert Benamouzig5. 1. Physiology Department, Université René Descartes, Paris V, Paris, France. michel.bouchoucha@avc.aphp.fr. 2. Gastroenterology Department, Avicenne Hospital, Bobigny, France. michel.bouchoucha@avc.aphp.fr. 3. Diabetes, Nutrition and Endocrinology Department, Avicenne Hospital, Bobigny, France. 4. Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), UFR SMBH 74 rue Marcel Cachin, 93017, Bobigny, France. 5. Gastroenterology Department, Avicenne Hospital, Bobigny, France. 6. Surgical Department, Delafontaine Hospital, Saint Denis, France.
Abstract
BACKGROUND: Obesity is considered as a risk factor for many functional gastrointestinal disorders. The aim of the study was to evaluate if functional digestive disorders are associated with specific body mass index groups and gender. METHODS: A total of 1074 patients (50.3 ± 16.5 years, 67 % females) filled out a standard Rome III questionnaire (79 % acceptance rate). The patients were assigned to five groups according to their body mass index: underweight (6 %), normal (49 %), overweight (28 %), obese (12 %), and morbidly obese (5 %). Data analysis was performed using multinomial logistic regression; subjects with the normal weight were the reference group. RESULTS: Patients presented specific demographic and clinical characteristics according to the weight groups. Underweight patients were younger (p < 0.001), and presented a female predominance (p = 0.006), dysphagia (p = 0.013) and soiling (p = 0.021). Overweight patients were older (p = 0.001), and reported more frequently globus (p = 0.001), regurgitation (p = 0.004), postprandial distress syndrome (p = 0.009). Obese patients reported more frequently regurgitation (p < 0.001). Morbid obese patients reported dyspepsia (p = 0.046). In patients, the odds of regurgitation increased with body mass index from underweight to obesity, but not when compared to morbid obesity. The probability of globus and regurgitation increased with body mass index and presented a steeper increase in females. CONCLUSIONS: In patients with functional gastrointestinal disorders, globus and regurgitation are associated with body mass index, mainly in female patients.
BACKGROUND:Obesity is considered as a risk factor for many functional gastrointestinal disorders. The aim of the study was to evaluate if functional digestive disorders are associated with specific body mass index groups and gender. METHODS: A total of 1074 patients (50.3 ± 16.5 years, 67 % females) filled out a standard Rome III questionnaire (79 % acceptance rate). The patients were assigned to five groups according to their body mass index: underweight (6 %), normal (49 %), overweight (28 %), obese (12 %), and morbidly obese (5 %). Data analysis was performed using multinomial logistic regression; subjects with the normal weight were the reference group. RESULTS:Patients presented specific demographic and clinical characteristics according to the weight groups. Underweight patients were younger (p < 0.001), and presented a female predominance (p = 0.006), dysphagia (p = 0.013) and soiling (p = 0.021). Overweight patients were older (p = 0.001), and reported more frequently globus (p = 0.001), regurgitation (p = 0.004), postprandial distress syndrome (p = 0.009). Obesepatients reported more frequently regurgitation (p < 0.001). Morbid obesepatients reported dyspepsia (p = 0.046). In patients, the odds of regurgitation increased with body mass index from underweight to obesity, but not when compared to morbid obesity. The probability of globus and regurgitation increased with body mass index and presented a steeper increase in females. CONCLUSIONS: In patients with functional gastrointestinal disorders, globus and regurgitation are associated with body mass index, mainly in female patients.
Authors: Jean Paul Galmiche; Ray E Clouse; András Bálint; Ian J Cook; Peter J Kahrilas; William G Paterson; Andre J P M Smout Journal: Gastroenterology Date: 2006-04 Impact factor: 22.682
Authors: Ray E Clouse; Emeran A Mayer; Qasim Aziz; Douglas A Drossman; Dan L Dumitrascu; Hubert Mönnikes; Bruce D Naliboff Journal: Gastroenterology Date: 2006-04 Impact factor: 22.682