H Cho1,2, C Kim3, H J Kim1, B S Ye4, Y J Kim1, N-Y Jung1, T O Son1, E B Cho1, H Jang1, J Lee1, M Kang5, H-Y Shin5, S Jeon6, J-M Lee6, S T Kim7, Y-C Choi2, D L Na1,8,9, S W Seo1,8,9. 1. Department of Neurology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea. 2. Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 3. Department of Preventive Medicine and the Institute for Environmental Research, Yonsei University College of Medicine, Seoul, Korea. 4. Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. 5. Centre for Health Promotion, Samsung Medical Centre, Seoul, Korea. 6. Department of Biomedical Engineering, Hanyang University, Seoul, Korea. 7. Radiology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea. 8. Neuroscience Centre, Samsung Medical Centre, Seoul, Korea. 9. Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea.
Abstract
BACKGROUND AND PURPOSE: Smoking is a major risk factor for cognitive decline and dementia. However, the exact pathobiology of smoking remains unknown. The effects of smoking on cortical thickness as a biomarker of neurodegeneration or white matter hyperintensities and lacunes as biomarkers of cerebrovascular burden were concurrently evaluated. METHODS: Our study included 977 cognitively normal men who visited a health promotion centre and underwent medical check-ups, including 3.0 T magnetic resonance imaging. Participants were categorized into never smoker, past smoker or current smoker groups and pack-years and the years of smoking cessation were used as continuous variables. RESULTS: The current smoker group exhibited cortical thinning in frontal and temporo-parietal regions compared with the never smoker group. These effects were particularly prominent in smokers with a high cumulative exposure to smoking in the current smoker group. However, there was no association between smoking and the severity of white matter hyperintensity or number of lacunes. CONCLUSION: Our findings indicate that smoking might impact on neurodegeneration rather than cerebrovascular burdens in cognitively normal men, suggesting that smoking might be an important modifiable risk factor for the development of Alzheimer's disease.
BACKGROUND AND PURPOSE: Smoking is a major risk factor for cognitive decline and dementia. However, the exact pathobiology of smoking remains unknown. The effects of smoking on cortical thickness as a biomarker of neurodegeneration or white matter hyperintensities and lacunes as biomarkers of cerebrovascular burden were concurrently evaluated. METHODS: Our study included 977 cognitively normal men who visited a health promotion centre and underwent medical check-ups, including 3.0 T magnetic resonance imaging. Participants were categorized into never smoker, past smoker or current smoker groups and pack-years and the years of smoking cessation were used as continuous variables. RESULTS: The current smoker group exhibited cortical thinning in frontal and temporo-parietal regions compared with the never smoker group. These effects were particularly prominent in smokers with a high cumulative exposure to smoking in the current smoker group. However, there was no association between smoking and the severity of white matter hyperintensity or number of lacunes. CONCLUSION: Our findings indicate that smoking might impact on neurodegeneration rather than cerebrovascular burdens in cognitively normal men, suggesting that smoking might be an important modifiable risk factor for the development of Alzheimer's disease.
Authors: Whitney A Ratliff; Jessica N Saykally; Kristen L Keeley; David C Driscoll; Kathleen E Murray; Maja Okuka; Ronald F Mervis; Vedad Delic; Bruce A Citron Journal: Cell Mol Neurobiol Date: 2021-01-08 Impact factor: 5.046
Authors: Na-Yeon Jung; Hanna Cho; Yeo Jin Kim; Hee Jin Kim; Jong Min Lee; Seongbeom Park; Sung Tae Kim; Eun-Joo Kim; Jae Seung Kim; Seung Hwan Moon; Jae-Hong Lee; Michael Ewers; Duk L Na; Sang Won Seo Journal: Alzheimers Res Ther Date: 2018-09-27 Impact factor: 6.982